在妊娠后早期发育过程中,马近端芝麻状骨的矿化先于关节软骨和纤维软骨内膜的成熟。

IF 1.3 3区 农林科学 Q2 VETERINARY SCIENCES American journal of veterinary research Pub Date : 2024-07-31 Print Date: 2024-10-01 DOI:10.2460/ajvr.24.04.0101
Mana Okudaira, Erin N Cresswell, Caroline W Wollman, Sean P McDonough, Julie B Engiles, Heidi L Reesink
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引用次数: 0

摘要

目的使用放射摄影、微型计算机断层扫描(microcomputed (micro)-CT)和组织学方法描述胎马和幼马近端芝麻状骨(PSBs)的发育和成熟情况:描述性研究。方法:这是一项描述性研究。对 12 匹马的前肢 PSB 进行了评估,这些马的年龄从妊娠 105 天到妊娠后 540 天不等。射线照相术用于初步评估掌指关节和PSB矿化情况,显微CT成像用于评估矿化的PSB。组织体积、骨体积分数、高度、宽度、深度、骨小梁厚度和各向异性均通过三维平面显微CT切片进行量化。用 H&E 和 Safranin O/Fast Green 染色的 PSB 中矢状面组织学切片被用来确定骨化中心与软骨模板大小的比例,并描述软骨模板、骨化中心、球形生长板、关节软骨和粘连的形成和发展:结果:马PSB的矿化与软骨通道和球形生长板有关,球形生长板在妊娠晚期至妊娠早期发生软骨内骨化。顶端、挠骨、基底和关节骨化前沿表现出形态上的可变性。关节软骨和粘连的结构组织与下层密实骨板的发育同时进行。妊娠后540天时,PSB屈肌皮质的纤维软骨粘连尚未成熟:结论:在妊娠晚期至妊娠早期,马 PSB 主要通过软骨内骨化实现矿化。矿化先于关节软骨和纤维软骨粘连的成熟:PSB及其周围组织的妊娠后成熟可能使幼马容易在这些部位发生病变,如顶端撕脱性骨折,值得进一步研究。
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Mineralization of equine proximal sesamoid bones precedes articular cartilage and fibrocartilaginous enthesis maturation in early postgestational development.

Objective: To describe the development and maturation of equine proximal sesamoid bones (PSBs) in fetuses and young horses using radiography, microcomputed (micro)-CT, and histology.

Methods: A descriptive study. Forelimb PSBs from 12 equids ranging in age from 105 days of gestation to 540 days postgestation were evaluated. Radiography was used for preliminary assessment of metacarpophalangeal joint and PSB mineralization, and micro-CT imaging was performed to assess mineralized PSBs. Tissue volume, bone volume fraction, height, width, depth, trabecular thickness, and anisotropy were quantified from midplanar micro-CT sections in 3 dimensions. Midsagittal PSB histologic sections stained with H&E and Safranin O/Fast Green were used to determine the ratio of ossification center to cartilage template size and to describe the formation and development of the cartilage template, ossification center, spherical growth plate, articular cartilage, and entheses.

Results: Mineralization of equine PSBs is associated with cartilage canals and a spherical growth plate that undergoes endochondral ossification during the late gestation to early postgestational period. The apical, flexor, basilar, and articular ossification fronts demonstrate morphologic variability. Structural organization of the articular cartilage and entheses occurs concurrently with the development of an underlying plate of compact bone. At 540 days postgestation, the fibrocartilaginous entheses of the flexor cortex of the PSB had yet to mature.

Conclusions: Equine PSBs mineralize predominantly by endochondral ossification during the late gestation to early postgestational period. Mineralization precedes maturation of the articular cartilage and fibrocartilaginous entheses.

Clinical relevance: The postgestational maturation of the PSB and its surrounding tissues may predispose young horses to developing lesions at these sites, such as apical avulsion fractures, warranting further investigation.

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来源期刊
CiteScore
1.70
自引率
10.00%
发文量
186
审稿时长
3 months
期刊介绍: The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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