补充苏木(Rhus coriaria L.)粉对超重或肥胖的非酒精性脂肪肝患者的生化指标和人体测量指标的疗效:双盲随机对照试验。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI:10.22038/AJP.2024.23927
Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi
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引用次数: 0

摘要

研究目的本研究旨在评估苏木补充剂对超重或肥胖的非酒精性脂肪肝患者的生化指标和人体测量指标的影响:在这项双盲随机对照试验中,45名非酒精性脂肪肝患者被随机分为两组。干预组服用苏木胶囊(3 克/天)并搭配均衡饮食,为期 8 周;安慰剂组服用安慰剂并搭配均衡饮食,为期 8 周。在基线和研究结束时测量人体测量指数、血脂概况、空腹血糖、胰岛素、胰岛素抵抗自律模型评估、天门冬氨酸转氨酶、丙氨酸氨基转移酶、高敏C反应蛋白和丙二醛:结果显示,人体测量指数(体重(p=0.001)、体重指数(p=0.001)、腰围(p=0.001)、体脂质量(p=0.001)、体脂百分比(p=0.001)、内脏脂肪评分(p=0.001)、总胆固醇(p=0.007)、空腹血糖(p=0.006)、胰岛素(p=0.004)和 HOMA-IR (p=0.002)的生化水平)。然而,在人体测量和生化指标方面,两组之间没有观察到明显差异:在这项研究中,没有观察到两组之间在人体测量和生化指标方面存在明显差异。因此,建议就此问题开展样本量更大的进一步研究。
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The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.

Objective: This study aimed to assess the effect of sumac supplement in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease.

Materials and methods: In this double-blind randomized controlled trial, 45 NAFLD patients were randomly divided into two groups. The intervention group received sumac capsules (3 g/day) with a balanced diet for 8 weeks, while the placebo group received placebo with a balanced diet. Anthropometric indices, lipid profile, fasting blood glucose, insulin, Homeostatic Model Assessment for Insulin Resistance, aspartate transaminase, alanine aminotransferase, high sensitivity C-reactive protein and malondialdehyde were measured at baseline and at the end of the study.

Results: The results revealed a significant decrease in anthropometric indices (weight (p=0.001), body mass index (p=0.001), waist circumference (p=0.001), body fat mass (p=0.001), body fat percentage (p=0.001), visceral fat score (p=0.001), biochemical levels of total cholesterol (p=0.007), fasting blood sugar (p=0.006), insulin (p=0.004) and HOMA-IR (p=0.002)) after the intervention compared to the baseline. However, no significant difference was observed between the two groups concerning anthropometric and biochemical indices.

Conclusion: In this study, no significant differences were observed between the two groups regarding anthropometric and biochemical indices. Thus, further studies with larger sample sizes are recommended to be conducted on the issue.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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