野生苦瓜在小鼠模型中改善肌肉萎缩的治疗潜力。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI:10.22038/AJP.2024.24011
Sima Seifi, Seyedeh Elnaz Nazari, Amir Avan, Nima Khalili-Tanha, Fatemeh Babaei, Saman Soleimanpour, Fereshteh Asgharzadeh, Mousa-Al-Reza Hajzadeh, Majid Khazaei, Abdoljalal Marjani
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引用次数: 0

摘要

目的:肌肉萎缩是许多疾病的常见并发症,也是治疗过程的一个结果。不动和不活动已被证明与炎症加剧有关。本研究的目的是调查野生苦瓜(WBM)(Momordica charantia Linn)对小鼠模型中因静止不动导致的肌肉萎缩的治疗潜力:本研究以雄性 BALB/c 小鼠为研究对象,分为对照组、固定组和实验组,分萎缩和恢复两个阶段进行。每天灌胃 400 毫克/千克剂量的 WBM 治疗期为 17 天,其中包括 7 天的固定期和 10 天的恢复期。每个阶段结束时,对每组一半的小鼠进行四肢握力检查,然后进行组织学和生化分析:结果:萎缩组萎缩期组织丙二醛(MDA)氧化应激指数水平(5.4567±0.522)nmol/g与对照组(3.455±0.065)nmol相比有显著性差异(P 0.001):结果表明,使用 WBM 可降低炎症、氧化应激和肌肉损伤程度以及肌肉萎缩程度,从而改善小鼠的肌肉萎缩状况。
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The therapeutic potential of Wild Bitter Melon to ameliorate muscle atrophy in a murine model.

Objective: Muscle atrophy due to immobility is a common complication of many diseases and a consequence of therapeutic processes. Immobility and inactivity have been shown to be associated with increased inflammation. The aim of this study was to investigate the therapeutic potential of Wild Bitter Melon (WBM) (Momordica charantia Linn) on muscle atrophy due to immobility in a mouse model.

Materials and methods: This study was performed in two phases of atrophy and recovery on male BALB/c mice which were divided into 3 groups: control, immobilized, and experimental. The treatment period with WBM at a dose of 400 mg/kg daily by gavage was 17 days, including 7 days of being immobilized and 10 days of recovery. At the end of each phase, half of the mice from each group were examined regarding the four limb grip strength, and then histological and biochemical analyses were done.

Results: The tissue level of malondialdehyde (MDA) oxidative stress index in the atrophy phase in the atrophy group (5.4567±0.522) nmol/g compared to the control group (3.455±0.065) nmol significantly (p 0.001) <) increased. Also, the tissue level of MDA in the WBM group (3.87±0.035) showed a significant decrease compared to the atrophy group (p<0.01). The strength percentage of four limbs in the mice of the treatment group (-23.46±2.45) was significantly higher than that of the atrophy group (-30.60±3.15) at the end of the atrophy phase.

Conclusion: The results suggest that the use of WBM reduces the degree of inflammation, oxidative stress and muscle damage, as well as muscle atrophy, which may improve the muscle atrophy in mice.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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