利用吲哚菁绿的近红外荧光成像技术经皮检测皮肤黑色素瘤的前哨淋巴结。

IF 1.5 4区 医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-08-02 DOI:10.1097/CMR.0000000000000994
Bo E Zweedijk, Antonius W Schurink, Thijs van Dalen, Tessa M van Ginhoven, Cornelis Verhoef, Bernd Kremer, Denise E Hilling, Stijn Keereweer, Dirk J Grünhagen
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引用次数: 0

摘要

这项研究旨在评估吲哚菁绿(ICG)荧光能否取代锝,用于术前检测皮肤黑色素瘤的前哨淋巴结(SLN)。目前,前哨淋巴结检测的黄金标准是放射性同位素锝。使用 ICG 进行荧光成像(FLI)是一种很有前途的替代方法。在这项研究中,我们招募了2022年11月至2023年7月期间在伊拉斯姆斯医学中心接受皮肤黑色素瘤前哨淋巴结活检(SLNB)的患者。前哨淋巴结活检手术按标准护理进行。全身麻醉后,在原发肿瘤周围皮内注射 ICG。患者和外科医生对 SLN 的位置均不设盲区。FLI 在切口前、切口后和体外进行。所有病例都使用伽马探针确认了荧光 SLN。本研究共纳入 32 名患者,共采集了 39 个 SLN。ICG 经皮检测率为 21.9%。体内ICG荧光和锝吸收率合计为94.9%。一个 SLN 仅含有 ICG(2.6%),一个 SLN 仅含有锝吸收(2.6%)。使用 ICG 进行 FLI 的经皮检测率相对较低,这意味着完全使用目前的这种技术是不可行的。不过,我们确实发现了 ICG 在 SLN 中的大量积聚,这表明 ICG 与其他成像技术结合使用的潜力。
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Transcutaneous sentinel lymph node detection in skin melanoma with near-infrared fluorescence imaging using indocyanine green.

The aim of the study is to assess whether indocyanine green (ICG) fluorescence can replace technetium in the preoperative detection of sentinel lymph nodes (SLN) from cutaneous melanoma. The current golden standard for SLN detection is the radioisotope technetium. A promising alternative is fluorescence imaging (FLI) using ICG. In this study, we enrolled patients undergoing sentinel lymph node biopsy (SLNB) for skin melanoma at the Erasmus Medical Center between November 2022 and July 2023. The SLNB procedure was performed as a standard of care. After general anesthesia, ICG was injected intradermally around the primary tumor site. Both the patient and the surgeon were not blinded for the location of the SLN. FLI was performed before incision, in vivo after incision, and ex vivo. Fluorescent SLNs were confirmed using the gamma probe in all cases. Thirty-two patients were included in this study, and a total of 39 SLNs were harvested. The transcutaneous detection rate of ICG was 21.9%. The combined ex vivo ICG fluorescence and technetium uptake was 94.9%. One SLN contained only ICG (2.6%) and one SLN contained only technetium-uptake (2.6%). FLI using ICG resulted in a relatively low transcutaneous detection, which means that exclusive use of this technique in its present form is not feasible. However, we did find a high accumulation of ICG in the SLN, indicating the potential of ICG in combination with other imaging techniques.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
期刊最新文献
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