Marlene Oefele, Michaela Hau, Suvi Ruuskanen, Stefania Casagrande
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引用次数: 0
摘要
生物体对环境的反应主要取决于有氧线粒体代谢通过三磷酸腺苷(ATP)产生的能量供应变化。ATP 在能量需求条件下尤其重要,例如在快速生长期间。目前,人们对环境因素如何影响能量代谢和线粒体功能还知之甚少,但最近的研究表明甲状腺激素(TH)发挥了作用。甲状腺激素是生长和新陈代谢的关键调节因子,可根据环境温度或食物供应等环境条件灵活调节。为了检验甲状腺激素的增强是否与线粒体功能和生长有因果关系,我们在斑马雀(Taeniopygia guttata)雏鸟的主要生长阶段口服了生理浓度的甲状腺激素。TH 处理可加速线粒体的最大工作能力--这一特性反映了线粒体 ATP 的产生,而不影响生长。据我们所知,这是首次在半自然环境下研究线粒体在发育过程中受TH调控的特性,并探讨其对生长等体能相关性状的影响。
Mitochondrial function is enhanced by thyroid hormones during zebra finch development.
An organism's response to its environment is largely determined by changes in the energy supplied by aerobic mitochondrial metabolism via adenosine triphosphate (ATP) production. ATP is especially important under energy-demanding conditions, such as during rapid growth. It is currently poorly understood how environmental factors influence energy metabolism and mitochondrial functioning, but recent studies suggest the role of thyroid hormones (TH). TH are key regulators of growth and metabolism and can be flexibly adjusted to environmental conditions, such as environmental temperature or food availability. To test whether TH enhancement is causally linked to mitochondrial function and growth, we provided TH orally at physiological concentrations during the main growth phase in zebra finch (Taeniopygia guttata) nestlings reared in a challenging environment. TH treatment accelerated maximal mitochondrial working capacity-a trait that reflects mitochondrial ATP production, without affecting growth. To our knowledge, this is the first study to characterize the regulation of mitochondria by TH during development in a semi-naturalistic context and to address implications for fitness-related traits, such as growth.
期刊介绍:
Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review.
The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.