姜酮对多柔比星诱导的大鼠肝毒性氧化应激的保护作用

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2024-01-01 DOI:10.61186/rbmb.12.4.575
Rezvan Motamedi, Soheila Aminzadeh, Mohammad Javad Khodayar, Layasadat Khorsandi, Maryam Salehcheh
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引用次数: 0

摘要

背景:多柔比星是一种常用的蒽环类抗生素和化疗药物:多柔比星是一种常用的蒽环类抗生素和化疗药物,其不良反应之一是肝毒性。本研究旨在评估姜酮(一种从生姜中提取的生物活性化合物,因其抗氧化特性而闻名)对多柔比星诱导的大鼠肝毒性氧化应激的保护作用:在这项实验研究中,48 只雄性 Wistar 大鼠被分成六个不同的组。第一组接受生理盐水对照治疗。第二组在第 5 天腹腔注射 20 毫克/千克多柔比星。第三组连续 8 天口服每公斤 40 毫克的金格列酮。第四组、第五组和第六组在同样的 8 天内分别服用了剂量为 10、20 和 40 毫克/千克的姜酮。第 5 天,除对照组外,其他各组均腹腔注射多柔比星。间隔 72 小时后,对动物进行麻醉,并采集血液样本以评估血清因子。此外,还对部分肝组织进行了组织病理学分析和氧化应激参数评估:结果:多柔比星组的血清酶活性水平升高,包括天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和肝脏丙二醛(MDA)。相反,谷胱甘肽过氧化物酶(GPX)、超氧化物歧化酶(SOD)和谷胱甘肽(GSH)等其他参数的水平则有所下降。然而,同时服用姜酮能有效逆转这些水平,使其恢复正常:这些研究结果表明,姜酮,尤其是高剂量姜酮,在多柔比星诱导的肝毒性模型中具有保肝作用。
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Protective Effects of Zingerone on Oxidative Stress in Doxorubicin-Induced Rat Hepatotoxicity.

Background: Doxorubicin, a commonly utilized anthracycline antibiotic and chemotherapeutic agent, has been associated with hepatotoxicity as an adverse effect. This study aimed to evaluate protective effects of zingerone, a bioactive compound derived from ginger renowned for its antioxidative attributes, on oxidative stress in doxorubicin-induced rat hepatotoxicity.

Methods: In this experimental study, a total of 48 male Wistar rats were allocated into six distinct groups. The first group received a control treatment of normal saline. The second group was administered an intraperitoneal dose of 20 mg/kg of doxorubicin on day 5. The third group received an oral dose of 40 mg/kg of zingerone for 8 days. The fourth, fifth, and sixth groups were administered zingerone at doses of 10, 20, and 40 mg/kg, respectively, for the same 8-day period. On day 5, all groups, except the control group, received an intraperitoneal injection of doxorubicin. Following a 72-hour interval, the animals were anesthetized, and blood samples were collected to assess serum factors. Moreover, portions of the liver tissue were subjected to histopathological analysis and assessment of oxidative stress parameters.

Results: The activity levels of serum enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), and liver malondialdehyde (MDA), increased in the doxorubicin group. Conversely, the levels of other parameters such as glutathione peroxidase (GPX), superoxide dismutase (SOD), and glutathione (GSH) decreased. However, the co-administration of zingerone effectively reversed these levels, restoring them back to normal.

Conclusions: These findings suggest that zingerone, particularly at a high dose, exhibit a hepatoprotective effect in the doxorubicin-induced hepatotoxicity model.

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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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