{"title":"通过微流控阻抗能谱对电解质浓度进行纯电检测","authors":"","doi":"10.1016/j.xcrp.2024.102133","DOIUrl":null,"url":null,"abstract":"<p>Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl<sub>2</sub>, and MgCl<sub>2</sub>. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy\",\"authors\":\"\",\"doi\":\"10.1016/j.xcrp.2024.102133\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl<sub>2</sub>, and MgCl<sub>2</sub>. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.</p>\",\"PeriodicalId\":9703,\"journal\":{\"name\":\"Cell Reports Physical Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-07-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Reports Physical Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xcrp.2024.102133\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Reports Physical Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.xcrp.2024.102133","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Purely electrical detection of electrolyte concentration through microfluidic impedance spectroscopy
Impedance spectroscopy enables the electrical properties of samples to be probed and is commonly used to characterize solids. Extending this technique to analyze fluids within microfluidic channels could enable the rapid characterization of bodily fluids such as sweat. Here, we present a low-cost microfluidic platform with integrated aerosol-jet printed electrodes for the electrical characterization of fluids via impedance spectroscopy. A novel analysis method is presented to accurately determine the concentration of several aqueous ionic chloride solutions, namely NaCl, KCl, CaCl2, and MgCl2. Importantly, we identify a key parameter, the turning point frequency of the capacitance-frequency graph, which is found to have a highly linear correlation with the solution concentration for each species spanning at least three orders of magnitude. This linear dependence is highly reproducible across different cationic species, making it useful for accurate fluid characterization. Applying this technique to analyze bodily fluids in real time has implications for remote health monitoring.
期刊介绍:
Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.