月见草的抗氧化和抗霉菌毒素作用对樱桃谷鸭黄曲霉毒素病的影响

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-07-27 DOI:10.3390/toxins16080334
Chompunut Lumsangkul, Phruedrada Kaewtui, Kiattisak Huanhong, Ko-Hua Tso
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引用次数: 0

摘要

本研究旨在评估樱桃谷鸭日粮中黄曲霉毒素B1(AFB1)和月见草提取物(TLE)的效果。我们的研究涵盖了生长指标、血液生化指标、肉质、肠道形态、免疫反应和 CP450 酶相关基因表达。我们以 180 只七日龄的樱桃谷鸭为研究对象,随机分为五个日粮处理。这些处理包括不含 AFB1(T1 组)、TLE 或商用粘合剂的基础日粮;分别含 0.1 毫克 AFB1/千克(T2 组)、0.1 毫克 AFB1/千克和 100 毫克 TLE/千克(T3 组)、0.1 毫克 AFB1/千克和 200 毫克 TLE/千克(T4 组)以及 0.1 毫克 AFB1/千克和 0.5 克/千克商用粘合剂(T5 组)的基础日粮。在为期 42 天的试验中,饲喂 T2 日粮的雏鸭的最终体重(BW)、平均增重(ADG)和饲料转化率(FCR)均较低。然而,与 T2 组相比,T3、T4 和 T5 组的所有雏鸭在最终体重、平均增重和饲料转化率方面都有显著改善。饲喂 T2 日粮的雏鸭丙氨酸转氨酶(ALT)浓度升高,CYP1A1 和 CYP1A2 的表达增加,这表明雏鸭存在肝毒性。相反,饲喂 T3、T4 和 T5 日粮的雏鸭 CYP1A1 和 CYP1A2 的表达均有所下降,但只有 T4 处理组的 ALT 浓度有所改善。AFB1毒性显著增加了T2组十二指肠和空肠的隐窝深度(CD),而给予200毫克TLE/千克(T4)或商业粘合剂(T5)可有效降低这种毒性。此外,T2 治疗组的空肠绒毛宽度显著下降,而所有 T3、T4 和 T5 组在这方面都有所改善。总之,月桂叶提取物可对黄曲霉毒素中毒进行解毒,从而导致樱桃谷鸭的生长下降和肝中毒。
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Antioxidative and Antimycotoxigenic Efficacies of Thunbergia laurifolia Lindl. for Addressing Aflatoxicosis in Cherry Valley Ducks
This study aimed to assess the effectiveness of aflatoxin B1 (AFB1) and Thunbergia laurifolia extract (TLE) in the diets of Cherry Valley ducklings. Our investigation covered growth indicators, blood biochemical indices, meat quality, intestinal morphology, immune response, and CP450 enzyme-related gene expression. We conducted the study with 180 seven-day-old Cherry Valley ducks, randomly divided into five dietary treatments. These treatments included a basal diet without AFB1 (T1 group), TLE, or a commercial binder; the basal diet containing 0.1 mg AFB1/kg (T2 group), 0.1 mg AFB1/kg and 100 mg TLE/kg (T3 group), 0.1 mg AFB1/kg and 200 mg TLE/kg (T4 group), and 0.1 mg AFB1/kg and 0.5 g/kg of a commercial binder (T5 group), respectively. Ducklings fed with the T2 diet exhibited lower final body weight (BW), average body weight gain (ADG), and poor feed conversion ratio (FCR) during the 42-day trials. However, all ducklings in the T3, T4, and T5 groups showed significant improvements in final BW, ADG, and FCR compared to the T2 group. Increased alanine transaminase (ALT) concentration and increased expression of CYP1A1 and CYP1A2 indicated hepatotoxicity in ducklings fed the T2 diet. In contrast, ducklings fed T3, T4, and T5 diets all showed a decrease in the expression of CYP1A1 and CYP1A2, but only the T4 treatment group showed improvement in ALT concentration. AFB1 toxicity considerably raised the crypt depth (CD) in both the duodenum and jejunum of the T2 group, while the administration of 200 mg TLE/kg (T4) or a commercial binder (T5) effectively reduced this toxicity. Additionally, the villus width of the jejunum in the T2 treatment group decreased significantly, while all T3, T4, and T5 groups showed improvement in this regard. In summary, T. laurifolia extract can detoxify aflatoxicosis, leading to growth reduction and hepatic toxicosis in Cherry Valley ducklings.
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