通过时域漫反射光学监控新辅助化疗:乳腺组织成分变化和胶原蛋白鉴别潜力

IF 2.9 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS Biomedical optics express Pub Date : 2024-06-27 DOI:10.1364/boe.527968
Nikhitha Mule, Giulia Maffeis, Rinaldo Cubeddu, Carolina Santangelo, Giampaolo Bianchini, Pietro Panizza, Paola Taroni
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引用次数: 0

摘要

这项临床研究的目的是测试宽光谱范围(635-1060 nm)时域漫射光学光谱在监测乳腺癌患者对新辅助化疗(NAC)反应方面的应用。宽带操作使我们能够全面分析血红蛋白、水、脂质和胶原蛋白浓度方面的组织成分,迄今为止,我们从未在治疗过程中对这些成分进行过系统研究。我们对患者进行了多次乳腺光学成像,每次成像都是在新农合的不同阶段对肿瘤患者和对侧健康乳房进行的。我们将光学成像结果与传统成像技术和病理反应相关联。10 名患者数据的初步结果显示,从基线到治疗结束,至少部分对治疗有反应的患者的肿瘤乳房中氧合血红蛋白(-53%,p = 0.0020)、胶原蛋白(-36%,p = 0.0039)和水(-15%,p = 0.0195)的浓度平均显著降低,而脂质(+39%,p = 0.0137)则有所增加。在散射方面,与基线相比,散射振幅a在治疗结束时略有增加(+15%,p = 0.0039),而散射斜率b则无明显变化(+4%,p = 0.9219)。对侧健康乳房中的成分浓度也发生了一些变化,但只有氧合血红蛋白浓度发生了显著变化。我们观察到,从基线算起,2-3 周后,胶原蛋白似乎是区分完全应答者和部分应答者的唯一成分。在完全应答组中,2-3 周后胶原蛋白与基线相比明显减少(p = 0.0423)。虽然部分反应者组也出现了下降,但未达到统计学意义(p = 0.1012)。这表明,胶原蛋白可作为一种潜在的生物标志物,在治疗早期衡量 NAC 的有效性。尽管这只是在一小部分患者身上获得的结果,但这些初步结果与标准医疗模式的结果一致,并凸显了该技术对 NAC 期间乳房成分变化的敏感性。
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Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential
The purpose of this clinical study is to test a broad spectral range (635-1060 nm) time-domain diffuse optical spectroscopy in monitoring the response of breast cancer patients to neoadjuvant chemotherapy (NAC). The broadband operation allows us to fully analyze tissue composition in terms of hemoglobin, water, lipids and collagen concentration, which has never been systematically studied until now during the course of therapy. Patients are subjected to multiple breast optical imaging sessions, each one performed at different stages of NAC, both on tumor-bearing and contralateral healthy breasts. We correlate the optical results with conventional imaging techniques and pathological response. Preliminary outcomes on 10 patients’ data show an average significant reduction in the concentrations of oxy-hemoglobin (-53%, p = 0.0020), collagen (-36%, p = 0.0039) and water (-15%, p = 0.0195), and increase in lipids (+39%, p = 0.0137) from baseline to the end of therapy in the tumor-bearing breast of patients who responded to therapy at least partially. With respect to scattering, the scattering amplitude, a, increases slightly (+15%, p = 0.0039) by the end of the therapy compared to the baseline, while the scattering slope, b, shows no significant change (+4%, p = 0.9219). Some change in the constituents’ concentrations was also noticed in the contralateral healthy breast, even though it was significant only for oxy-hemoglobin concentration. We observed that collagen seems to be the only component distinguishing between complete and partial responders by the end of 2-3 weeks from the baseline. In the complete responder group, collagen significantly decreased after 2-3 weeks with respect to baseline (p = 0.0423). While the partial responder group also showed a decrease, it did not reach statistical significance (p = 0.1012). This suggests that collagen could serve as a potential biomarker to measure NAC effectiveness early during treatment. Even though obtained on a small group of patients, these initial results are consistent with those of standard medical modalities and highlight the sensitivity of the technique to changes that occur in breast composition during NAC.
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来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
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