用于脱羧偶联的异质锌催化剂的合成与应用

IF 0.8 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Proceedings of the National Academy of Sciences, India Section A: Physical Sciences Pub Date : 2024-08-01 DOI:10.1007/s40010-024-00886-8

Jagdish Chandra Jat, Preeti Mehta

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摘要

摘要醛、胺和炔的偶联（称为 A3-偶联）是合成丙炔胺的一种通用策略，丙炔胺是生物活性分子的重要前体。最近，苯乙氧酸作为醛的替代物，在上述反应中通过脱羧偶联作用变得越来越重要。据报道，铜和金等过渡金属催化剂可用于该反应。然而，金属废料及其处理是化学工业面临的主要挑战。在这项工作中，我们探索了壳聚糖支撑的锌催化剂，用于苯乙酸与胺和炔的脱羧偶联反应。我们发现，在无溶剂条件下，该反应的产率最高。为了进行比较，我们还探讨了合成催化剂在各种分子溶剂中的催化活性。

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Synthesis and Application of Heterogeneous Zinc Catalysts for Decarboxylative Coupling

Abstract

The coupling of aldehyde, amine, and alkyne (known as A³-coupling) is a versatile strategy for the synthesis of propargylamines which are important precursors for the biologically active molecules. Recently, phenylglyoxylic acid as a surrogate of aldehyde has gained importance in the above reaction via decarboxylative coupling. Transition metal catalysts of Cu and Au have been reported for this reaction. However, metal waste and their disposal is the major challenge faced by chemical industries. In this work, we have explored chitosan-supported zinc catalysts for the decarboxylative coupling of phenylglyoxylic acid with amine and alkyne. We found that this reaction gives the best yield under solvent-less condition. For comparison purpose, the catalytic activity of synthesized catalysts in various molecular solvents has also been explored.