治疗特应性皮炎的多功能曲安奈德微针贴片

Liwan Song, Lu Fan, Qingfei Zhang, Shanshan Huang, Bin Kong, Jian Xiao, Ye Xu
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摘要

特应性皮炎(AD)是一种慢性炎症性皮肤病,给患者带来了巨大的生理和心理负担,引起了社会的广泛关注。本文提出的多功能微针(MN)贴片集成了理想的保湿剂和智能给药能力,可用于特应性皮炎的治疗。这种微针贴片由透明质酸(HA)衬底和含有黑磷量子点(BPQDs)、低熔琼脂糖、聚乙烯吡咯烷酮(PVP)和曲安奈德(TA)的近红外(NIR)响应尖端组成。其中,可溶性 HA 可作为缓解 AD 干燥症状的长期保湿剂。通过在琼脂糖中引入可激发近红外和光热响应的 BPQDs,可通过近红外智能调节复合材料的状态,从而实现可控地在尖端释放包裹的 TA。此外,具有足够机械强度的 PVP 还能帮助 MNs 成功穿透 AD 患者增厚的皮肤。基于这些优势,多功能 MN 贴片在 Balb/c 小鼠 AD 模型中显示出令人满意的治疗效果。这些结果表明了所提出的多功能 MN 贴片在治疗 AD 皮肤病和其他相关生物医学领域的潜在价值。
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Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment
Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug delivery capacity for AD treatment. Such MN patch consists of hyaluronic acid (HA) backing and near-infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low-melting agarose, polyvinylpyrrolidone (PVP), and triamcinolone acetonide (TA). Among them, the soluble HA serves as a long-term moisturizer for relieving dryness symptoms of AD. By introducing the NIR excitable and photothermal responsive BPQDs into agarose, the state of the composite material can be adjusted intelligently via NIR, thus achieving controllable release of the encapsulated TA in tips. Besides, PVP with enough mechanical strength can help MNs successfully penetrate the thickened skin of AD patients. Based on these advantages, it is demonstrated that the multifunctional MN patch reveals a satisfactory therapeutic effect in the AD model of Balb/c mice. These results indicate the potential values of the proposed MN patch in the treatment of AD skin diseases and other related biomedical fields.
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