不对称 N-杂环羰基金（I）络合物中的木糖：合成、表征和抗菌活性。

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL ChemMedChem Pub Date : 2024-08-01 DOI:10.1002/cmdc.202400245

Laura M H Pascual, Marius Colin, Aminou Mohamadou, Christelle Kowandy, Richard Plantier-Royon, Sylvain Gatard

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引用次数: 0

摘要

本研究以 D-木糖为原料，采用高效的方法制备了一系列含有非对称 N-杂环碳烯（咪唑亚基和苯并咪唑亚基）的 Au（I）复合物，这些 N-杂环碳烯由木糖基团和烷基（甲基和甲硅基）官能化。通过多核 NMR、HR-MS 光谱法和循环伏安法对它们的溶液特性进行了分析，并通过单晶 X 射线衍射分析对其中两种化合物的固态特性进行了分析。对它们抑制细菌生长的能力进行的评估显示，革兰氏阳性菌金黄色葡萄球菌比革兰氏阴性菌铜绿假单胞菌更受青睐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Xylose Incorporated in Unsymmetrical Gold(I) N-Heterocyclic Carbene Complexes: Synthesis, Characterization and Antibacterial Activity.

A series of Au(I) complexes containing unsymmetrical N-heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D-xylose. Their characterization was carried out in solution by multinuclear NMR, HR-MS spectrometry and cyclic voltammetry, as well as in the solid state by means of single crystal X-ray diffraction analysis for two of them. Evaluation of their ability to inhibit bacterial growth showed a preference for a Gram-positive strain, Staphylococcus aureus, over a Gram-negative strain, Pseudomonas aeruginosa.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.