从放线菌属诺卡氏菌中寻找天然产品。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2024-08-02 DOI:10.1007/s11418-024-01833-y

Yasumasa Hara

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引用次数: 0

摘要

诺卡氏菌属是革兰氏阳性细菌，其中许多具有致病性，可感染人类的肺、皮肤、大脑和其他器官。由于对诺卡氏菌属的研究进展不如链霉菌属那么迅速，因此诺卡氏菌属被认为是一种尚未开发的有用资源，可用于探索天然产品。另一方面，当诺卡氏菌属感染人体时，菌株会受到巨噬细胞等免疫细胞的攻击。因此，我们提出了一种在动物细胞存在下培养诺卡氏菌属来筛选天然产品的新方法。在这篇综述中，我们介绍了从诺卡氏菌属中寻找天然产品的最新成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Search for natural products from actinomycetes of the genus Nocardia

The genus Nocardia are gram-positive bacteria, many of which possess pathogenicity and infect human lungs, skin, brain, and other organs. Since research on the genus Nocardia has not progressed as rapidly as that on the genus Streptomyces, the genus Nocardia is considered a useful undeveloped resource for exploring natural products. On the other hand, when the genus Nocardia infects the human body, the strains are attacked by immune cells such as macrophages. Therefore, we suggested a new method for screening natural products by culturing the genus Nocardia in the presence of animal cells. In this review, we describe our recent results in searching for natural products from the genus Nocardia.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.