意大利患者中与格列汀相关大疱性类天疱疮易感性有关的 HLA 等位基因。

IF 5.9 4区医学 Q2 CELL BIOLOGY HLA Pub Date : 2024-08-02 DOI:10.1111/tan.15616

Marco Andreani, Feliciana Mariotti, Anna Pira, Franco Locatelli, Giuseppe Testa, Mariarosa Battarra, Priscilla Caputi, Alessandra Scarabello, Barbara Bellei, Cristiana Di Campli, Maria Chiara Collina, Ilaria Esposito, Anna Rita Giampetruzzi, Biagio Didona, Dario Pitocco, Clara De Simone, Giovanni Di Zenzo

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引用次数: 0

摘要

大疱性类天疱疮（BP）虽然罕见，却是最常见的表皮下自身免疫性疾病。据报道，使用用于治疗2型糖尿病的格列汀类药物治疗与大疱性类天疱疮的发病有关。为了确定可能反映意大利人群对 BP 较高易感性的 HLA 等位基因，我们分析了 30 名特发性大疱性类天疱疮（IBP）患者和 86 名格列汀相关性 BP（GABP）患者。结果发现，HLA-DQB1*03:01 等位基因与 IBP 和 GABP 患者之间存在明显关联。值得注意的是，IBP 和 GABP 均与以下单倍型之一有显著关联：DRB1*11:01、DRB3*02:02、DQA1*05:05、DQB1*03:01 或 DRB1*11:04、DRB3*02:02、DQA1*05:05 和 DQB1*03:01。这些数据首次发现了意大利人群中易患高血压的潜在标志物，尤其是与格列汀摄入量相关的标志物。

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HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients

Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.