成功实施并推动多通道腔内阻抗和 pH 值联合监测研究。

IF 3.8 Q2 GASTROENTEROLOGY & HEPATOLOGY Translational gastroenterology and hepatology Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI:10.21037/tgh-23-119
Frederick W Woodley, Jennifer M Miller, Carlo Di Lorenzo, Raul E Sanchez
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引用次数: 0

摘要

成功的多通道腔内阻抗和 pH 值监测(MII-pHM)研究需要固定的护理人员(CA)或家属(有时也包括患者本人)协助执行和促进 MII-pHM 研究。虽然在 MII-pHM 系统记录盒上 "按下按钮"(对应特定症状、身体姿势(直立或卧位)以及进餐开始和停止时间)确实是 MII-pHM 研究执行和促进的重要部分,但还有其他同样重要的关注点和职责。本文概述了研究促进者(或患者)在 MII-pHM 研究期间的一些重要职责。如果接受了适当的培训,监考 MII-pHM 研究的研究协助者将能更好地促进数据收集过程,并最终生成数据,这些数据经分析后将能产生更好的解释、临床建议和良好的临床结果。如果执行得当,MII-pHM 研究有可能评估食管粘膜对胃/十二指肠内容物的昼夜暴露情况,深入了解胃食管反流 (GER) 的近端范围,提供食管平均 pH 值的测量值,并评估粘膜完整性以及 GER 和相关症状之间的时间关系。虽然有多个团体就如何正确执行 MII-pHM 研究提出了建议,但据我们所知,还没有任何出版物将这些建议汇编成一份单一来源的文件。
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Executing and facilitating the successful combined multichannel intraluminal impedance and pH monitoring study.

Successful multichannel intraluminal impedance and pH monitoring (MII-pHM) studies rely on constant attendants (CAs) or family members (and sometimes the patients themselves) to assist in the execution and facilitation of the MII-pHM study. While "pushing buttons" [corresponding to specific symptoms, body position (upright versus recumbent), and meal start and stop times] on the MII-pHM system recording box is indeed a big part of MII-pHM study execution and facilitation, there are other concerns and duties that are equally as important. This paper outlines some of the important duties of the study facilitator (or patient) during a MII-pHM study. When provided with the proper training, study facilitators invigilating the MII-pHM study will be better able to contribute to the data collection process and ultimately to produce data that when analyzed will lead to better interpretations, clinical recommendations, and good clinical outcomes. When executed properly, MII-pHM studies have the potential to assess diurnal exposure of the esophageal mucosa to gastric/duodenal contents, provide insight regarding the proximal extent of gastroesophageal reflux (GER), provide a measurement of the mean esophageal pH, and assess mucosal integrity and temporal relationship between GER and the symptoms of interest. While several groups have offered recommendations for proper execution of the MII-pHM study, to our knowledge, there have not been publications wherein recommendations were compiled to form a single source document.

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