Hiora 的抗菌功效:阿育吠陀漱口水在儿童中的抗菌效果。

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1055/a-2368-4336
Sonali Saha, Kongkana Kalita, Kavita Dhinsa, Deval Kumar Arora, Brinda Suhas Godhi, Vidya Gowdappa Doddawad
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引用次数: 0

摘要

背景:漱口水作为一种抗菌给药系统,是最安全、最有效的载体之一,尤其是对幼儿而言。这是因为漱口水能够将治疗成分分布到所有可接触到的口腔表面,包括口腔近端区域:评估最近推出的阿育吠陀(Hiora)漱口水和三氯生漱口水在儿童中的抗菌效果:将 45 名 10-15 岁的健康儿童随机分为三组:草药漱口水(Hiora)组、三氯生漱口水(Kidodent)组以及作为对照组的生理盐水组。在使用研究用漱口水漱口前、漱口后 2 分钟、30 分钟和 60 分钟采集唾液样本。然后将这些样本接种到装有血琼脂培养基的培养皿中,在 37°C 的有氧和厌氧条件下培养 48 小时。对所产生的链球菌属和乳酸杆菌属细菌菌落进行计数(CFU/ml x 105)。统计分析包括方差分析、Newman Keul 的事后检验和双尾 "t "检验,以确定结果的显著性:结果:阿育吠陀希奥拉漱口水对唾液中链球菌属和乳酸杆菌属细菌菌落数的减少幅度最大,具有显著的统计学意义(p):阿育吠陀希奥拉漱口水的抗菌效果最高,其次是三氯生漱口水,依次递减,而生理盐水的抗菌效果最低。
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Antibacterial Efficacy of Hiora: An Ayurvedic Mouthwash in Children.

Background: Mouthwashes, as a form of antimicrobial delivery system, rank among the safest and most effective vehicles, particularly in the case of young children. This is attributed to their ability to distribute therapeutic components across all accessible oral surfaces, including interproximal areas.

Objective: To evaluate the antibacterial efficacy of recently introduced Ayurvedic (Hiora) and triclosan-based mouthwashes among children.

Materials and methods: A total of 45 healthy children aged 10-15 years were randomly assigned to three groups: Herbal mouthwash (Hiora), triclosan-based mouthwash (Kidodent), and normal saline as the control group. Saliva samples were collected pre-rinse, 2 minutes, 30 minutes, and 60 minutes post-rinsing with the study mouthwashes. These samples were then inoculated onto Petri dishes containing blood agar culture media, followed by incubation under both aerobic and anaerobic conditions at 37°C for 48 hours. The resulting bacterial colonies of Streptococcus spp. and Lactobacillus spp. were counted (CFU/ml x 105). Statistical analysis, including ANOVA, Newman Keul's Post-hoc test, and a two-tailed 't' test, was conducted to determine the significance of the results.

Results: The Ayurvedic Hiora mouthwash demonstrated the most substantial reduction in salivary bacterial colony counts of Streptococcus spp. and Lactobacillus spp. with statistically significant results (p<0.01).

Conclusion: The Ayurvedic Hiora mouthwash exhibited the highest antibacterial effectiveness, followed by the triclosan-based mouthwash in decreasing order, with saline showing the least efficacy.

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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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