D. Henares , V. Monsalvez , Pedro Brotons , Maria Luisa Machado , Silvia Capilla , Aina Gomila-Grange , Paula Bierge , Meritxell Cubero , Oscar Q. Pich , Ana Requena-Méndez , C. Muñoz-Almagro , O. Gasch
{"title":"与国际旅行有关的人类肠道微生物群组成。","authors":"D. Henares , V. Monsalvez , Pedro Brotons , Maria Luisa Machado , Silvia Capilla , Aina Gomila-Grange , Paula Bierge , Meritxell Cubero , Oscar Q. Pich , Ana Requena-Méndez , C. Muñoz-Almagro , O. Gasch","doi":"10.1016/j.tmaid.2024.102747","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food.</p></div><div><h3>Methods</h3><p>Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing.</p></div><div><h3>Results</h3><p>The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12<em>vs</em>3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1<em>vs</em>20.9). Specific genera enriched in travellers' gut microbiota were identified, including <em>Escherichia/Shigella, Bacteroides,</em> and <em>Parabacteroides</em>. The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of <em>Escherichia/Shigella,</em> exhibited the lowest levels of richness and diversity. The second cluster, dominated by <em>Faecalibacterium</em> and <em>Bacteroides</em>, displayed the highest richness and diversity patterns.</p></div><div><h3>Conclusion</h3><p>These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102747"},"PeriodicalIF":6.3000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000632/pdfft?md5=8379c9e1e0e1721a3e295756e8dec7e7&pid=1-s2.0-S1477893924000632-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Human gut microbiota composition associated with international travels\",\"authors\":\"D. Henares , V. Monsalvez , Pedro Brotons , Maria Luisa Machado , Silvia Capilla , Aina Gomila-Grange , Paula Bierge , Meritxell Cubero , Oscar Q. Pich , Ana Requena-Méndez , C. Muñoz-Almagro , O. Gasch\",\"doi\":\"10.1016/j.tmaid.2024.102747\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food.</p></div><div><h3>Methods</h3><p>Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing.</p></div><div><h3>Results</h3><p>The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12<em>vs</em>3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1<em>vs</em>20.9). Specific genera enriched in travellers' gut microbiota were identified, including <em>Escherichia/Shigella, Bacteroides,</em> and <em>Parabacteroides</em>. The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of <em>Escherichia/Shigella,</em> exhibited the lowest levels of richness and diversity. The second cluster, dominated by <em>Faecalibacterium</em> and <em>Bacteroides</em>, displayed the highest richness and diversity patterns.</p></div><div><h3>Conclusion</h3><p>These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications.</p></div>\",\"PeriodicalId\":23312,\"journal\":{\"name\":\"Travel Medicine and Infectious Disease\",\"volume\":\"61 \",\"pages\":\"Article 102747\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000632/pdfft?md5=8379c9e1e0e1721a3e295756e8dec7e7&pid=1-s2.0-S1477893924000632-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Travel Medicine and Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1477893924000632\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Travel Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1477893924000632","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Human gut microbiota composition associated with international travels
Objective
The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food.
Methods
Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing.
Results
The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12vs3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1vs20.9). Specific genera enriched in travellers' gut microbiota were identified, including Escherichia/Shigella, Bacteroides, and Parabacteroides. The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of Escherichia/Shigella, exhibited the lowest levels of richness and diversity. The second cluster, dominated by Faecalibacterium and Bacteroides, displayed the highest richness and diversity patterns.
Conclusion
These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications.
期刊介绍：
Travel Medicine and Infectious Disease
Publication Scope:
Publishes original papers, reviews, and consensus papers
Primary theme: infectious disease in the context of travel medicine
Focus Areas:
Epidemiology and surveillance of travel-related illness
Prevention and treatment of travel-associated infections
Malaria prevention and treatment
Travellers' diarrhoea
Infections associated with mass gatherings
Migration-related infections
Vaccines and vaccine-preventable disease
Global policy/regulations for disease prevention and control
Practical clinical issues for travel and tropical medicine practitioners
Coverage:
Addresses areas of controversy and debate in travel medicine
Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease
Publication Features:
Offers a fast peer-review process
Provides early online publication of accepted manuscripts
Aims to publish cutting-edge papers
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