Gina L Tripicchio , Alissa D Smethers , Jessica J Johnson , Jordan A Olenginski , Diane M O’Brien , Jennifer Orlet Fisher , Vitalina A Robinson , Sarah H Nash
{"title":"碳稳定同位素比（CIR）作为添加糖摄入量的客观生物标志物：人类营养学现有证据范围综述》。","authors":"Gina L Tripicchio , Alissa D Smethers , Jessica J Johnson , Jordan A Olenginski , Diane M O’Brien , Jennifer Orlet Fisher , Vitalina A Robinson , Sarah H Nash","doi":"10.1016/j.advnut.2024.100281","DOIUrl":null,"url":null,"abstract":"<div><p>Objective biomarkers of dietary intake are needed to advance nutrition research. The carbon isotope ratio (C<sup>13</sup>/C<sup>12</sup>; CIR) holds promise as an objective biomarker of added sugar (AS) and sugar-sweetened beverage (SSB) intake. This systematic scoping review presents the current evidence on CIRs from human studies. Search results (through April 12, 2024) yielded 6297 studies and 24 final articles. Studies were observational (<em>n</em> = 12), controlled feeding (<em>n</em> = 10), or dietary interventions (<em>n</em> = 2). CIRs were sampled from blood (<em>n</em> = 23), hair (<em>n</em> = 5), breath (<em>n</em> = 2), and/or adipose tissue (<em>n</em> = 1). Most (<em>n</em> = 17) conducted whole tissue (that is, bulk) analysis, 8 used compound specific isotope analysis (CSIA), and/or 2 studies used methods appropriate for analyzing breath. Studies were conducted in 3 concentrated geographic regions of the United States (<em>n</em> = 7 Virginia; <em>n</em> = 5 Arizona; <em>n</em> = 4 Alaska), with only 2 studies conducted in other countries. Studies that used CSIA to examine the CIR from the amino acid alanine (CIR-Ala; <em>n</em> = 4) and CIR analyzed from breath (<em>n</em> = 2) provided the most robust evidence for CIR as an objective biomarker of AS and SSBs (<em>R</em><sup>2</sup> range 0.36–0.91). Studies using bulk analysis of hair or blood showed positive, but modest and more variable associations with AS and SSBs (<em>R</em><sup>2</sup> range 0.05–0.48). Few studies showed no association, particularly in non-United States populations and those with low AS and SSB intakes. Two studies provided evidence for CIR to detect changes in SSB intake in response to dietary interventions. Overall, the most compelling evidence supports CIR-Ala as an objective indicator of AS intake and breath CIR as an indicator of short-term AS intake. Considering how to adjust for underlying dietary patterns remains an important area of future work and emerging methods using breath and CSIA warrant additional investigation. More evidence is needed to refine the utility and specificity of CIRs to measure AS and SSB intake.</p></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"15 9","pages":"Article 100281"},"PeriodicalIF":8.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2161831324001157/pdfft?md5=3ee75ff60a5fc2c1436520b795265149&pid=1-s2.0-S2161831324001157-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The Carbon Isotope Ratio as an Objective Biomarker of Added Sugar Intake: A Scoping Review of Current Evidence in Human Nutrition\",\"authors\":\"Gina L Tripicchio , Alissa D Smethers , Jessica J Johnson , Jordan A Olenginski , Diane M O’Brien , Jennifer Orlet Fisher , Vitalina A Robinson , Sarah H Nash\",\"doi\":\"10.1016/j.advnut.2024.100281\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Objective biomarkers of dietary intake are needed to advance nutrition research. The carbon isotope ratio (C<sup>13</sup>/C<sup>12</sup>; CIR) holds promise as an objective biomarker of added sugar (AS) and sugar-sweetened beverage (SSB) intake. This systematic scoping review presents the current evidence on CIRs from human studies. Search results (through April 12, 2024) yielded 6297 studies and 24 final articles. Studies were observational (<em>n</em> = 12), controlled feeding (<em>n</em> = 10), or dietary interventions (<em>n</em> = 2). CIRs were sampled from blood (<em>n</em> = 23), hair (<em>n</em> = 5), breath (<em>n</em> = 2), and/or adipose tissue (<em>n</em> = 1). Most (<em>n</em> = 17) conducted whole tissue (that is, bulk) analysis, 8 used compound specific isotope analysis (CSIA), and/or 2 studies used methods appropriate for analyzing breath. Studies were conducted in 3 concentrated geographic regions of the United States (<em>n</em> = 7 Virginia; <em>n</em> = 5 Arizona; <em>n</em> = 4 Alaska), with only 2 studies conducted in other countries. Studies that used CSIA to examine the CIR from the amino acid alanine (CIR-Ala; <em>n</em> = 4) and CIR analyzed from breath (<em>n</em> = 2) provided the most robust evidence for CIR as an objective biomarker of AS and SSBs (<em>R</em><sup>2</sup> range 0.36–0.91). Studies using bulk analysis of hair or blood showed positive, but modest and more variable associations with AS and SSBs (<em>R</em><sup>2</sup> range 0.05–0.48). Few studies showed no association, particularly in non-United States populations and those with low AS and SSB intakes. Two studies provided evidence for CIR to detect changes in SSB intake in response to dietary interventions. Overall, the most compelling evidence supports CIR-Ala as an objective indicator of AS intake and breath CIR as an indicator of short-term AS intake. Considering how to adjust for underlying dietary patterns remains an important area of future work and emerging methods using breath and CSIA warrant additional investigation. More evidence is needed to refine the utility and specificity of CIRs to measure AS and SSB intake.</p></div>\",\"PeriodicalId\":7349,\"journal\":{\"name\":\"Advances in Nutrition\",\"volume\":\"15 9\",\"pages\":\"Article 100281\"},\"PeriodicalIF\":8.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2161831324001157/pdfft?md5=3ee75ff60a5fc2c1436520b795265149&pid=1-s2.0-S2161831324001157-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2161831324001157\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2161831324001157","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
The Carbon Isotope Ratio as an Objective Biomarker of Added Sugar Intake: A Scoping Review of Current Evidence in Human Nutrition
Objective biomarkers of dietary intake are needed to advance nutrition research. The carbon isotope ratio (C13/C12; CIR) holds promise as an objective biomarker of added sugar (AS) and sugar-sweetened beverage (SSB) intake. This systematic scoping review presents the current evidence on CIRs from human studies. Search results (through April 12, 2024) yielded 6297 studies and 24 final articles. Studies were observational (n = 12), controlled feeding (n = 10), or dietary interventions (n = 2). CIRs were sampled from blood (n = 23), hair (n = 5), breath (n = 2), and/or adipose tissue (n = 1). Most (n = 17) conducted whole tissue (that is, bulk) analysis, 8 used compound specific isotope analysis (CSIA), and/or 2 studies used methods appropriate for analyzing breath. Studies were conducted in 3 concentrated geographic regions of the United States (n = 7 Virginia; n = 5 Arizona; n = 4 Alaska), with only 2 studies conducted in other countries. Studies that used CSIA to examine the CIR from the amino acid alanine (CIR-Ala; n = 4) and CIR analyzed from breath (n = 2) provided the most robust evidence for CIR as an objective biomarker of AS and SSBs (R2 range 0.36–0.91). Studies using bulk analysis of hair or blood showed positive, but modest and more variable associations with AS and SSBs (R2 range 0.05–0.48). Few studies showed no association, particularly in non-United States populations and those with low AS and SSB intakes. Two studies provided evidence for CIR to detect changes in SSB intake in response to dietary interventions. Overall, the most compelling evidence supports CIR-Ala as an objective indicator of AS intake and breath CIR as an indicator of short-term AS intake. Considering how to adjust for underlying dietary patterns remains an important area of future work and emerging methods using breath and CSIA warrant additional investigation. More evidence is needed to refine the utility and specificity of CIRs to measure AS and SSB intake.
期刊介绍：
Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments.
In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.
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