微血管密度和肿瘤相关巨噬细胞与口面部鳞状细胞癌进展的关系

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-06-24 DOI:10.1016/j.oooo.2024.06.013
Ayesha Irfan MPhil, MHPE , Ayesha Fahim PhD , Varda Jalil PhD , Nasar Um Min Allah MSD , Abeer Anjum MME , Remsha Mustafa MME , Habib Ahmad Qureshi MPhil , Fahim Haider Jafari PhD , Muhammad Amber Fareed PhD , Muhammad Sohail Zafar PhD
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引用次数: 0

摘要

本研究旨在调查巴基斯坦人群中肿瘤相关巨噬细胞(TAMs)的特征及其与不同等级口腔鳞状细胞癌(OSCC)肿瘤进展过程中微血管密度(MVD)的关系。这项前瞻性研究纳入了巴基斯坦不同医院报告的 234 名被诊断为 OSCC 的口腔癌患者。根据 Anneroth 分级系统对肿瘤进行了分级,并在体内检测了 TAMs 的频率与 MVD 之间的关联。在 3 个高倍视野中人工计数通过 CD68 免疫组化可见的巨噬细胞和通过 CD34 免疫组化观察到的微血管。与分化不良的鳞状细胞癌相比,分化良好的鳞状细胞癌的 CD68 和 CD34 数量明显较低。线性回归分析显示,CD68 免疫反应的面积百分比与肿瘤的分级呈正相关(r = 0.776)。反之亦然,CD34 免疫反应的面积百分比与肿瘤分级之间也存在正相关(r = 0.690)。皮尔逊相关性显示,TAMs 与 MVD 呈正相关(r = 0.680;< .001)。随着口腔鳞状细胞癌等级的升高,肿瘤相关巨噬细胞的数量和肿瘤血管生成也随之增加。(Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
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Relationship of microvascular density and tumor-associated macrophages with orofacial squamous cell carcinoma progression

Objective

The current study aimed to investigate the characteristics of tumor-associated macrophages (TAMs) and their association with microvascular density (MVD) in tumor progression in different grades of orofacial squamous cell carcinoma (OSCC) in the Pakistani population.

Study Design

This prospective study included 234 patients with oral cancer reported at different hospitals in Pakistan diagnosed with OSCC. Tumors were graded on the Anneroth grading system and the association between the frequency of TAMs and MVD was examined in vivo. The macrophages visible through immunohistochemistry for CD68 and the microvessels observed through immunohistochemistry for CD34 were manually counted in 3 high-power fields.

Results

The CD68 and CD34 counts were significantly lower in well-differentiated squamous cell carcinoma compared to poorly differentiated squamous cell carcinoma. Linear regression analysis revealed a positive correlation between the area percentage of CD68 immunoreactivity and the grade of the tumor (r = 0.776). Vice versa, a positive correlation also existed between the area percentage of CD34 immunoreactivity and the grade of the tumor (r = 0.690). Pearson correlation revealed a positive association between the TAMs and MVD (r = 0.680; P < .001).

Conclusions

There was an increased population of tumor-associated macrophages and tumor angiogenesis with the increasing grade of orofacial squamous cell carcinoma. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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