现代致癌环境对野生动物物种的适应性、进化和保护的复杂影响。

IF 3.5 2区 生物学 Q1 EVOLUTIONARY BIOLOGY Evolutionary Applications Pub Date : 2024-08-02 DOI:10.1111/eva.13763
Antoine M. Dujon, Beata Ujvari, Sophie Tissot, Jordan Meliani, Océane Rieu, Nikita Stepanskyy, Rodrigo Hamede, Jácint Tokolyi, Aurora Nedelcu, Frédéric Thomas
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引用次数: 0

摘要

越来越多的证据表明,人类活动正在导致人类和野生动物的癌症发病率上升。这是由于祖先的抗癌防御系统无法应对现代环境风险。现代致癌风险与已进化的癌症防御系统之间的进化不匹配在不同时间范围内对生物的各个方面产生了深远影响,需要对受影响物种的生物学和进化生态学进行全面研究。首先,抗癌防御系统的激活增加会导致能量消耗过多,影响其他生物功能,并可能引发自身免疫性疾病等健康问题。其次,肿瘤发生本身会影响与健康相关的重要参数,如竞争力、躲避捕食者、对寄生虫的抵抗力和扩散能力。第三,癌症风险的上升会影响物种的生活史特征,通常有利于早期繁殖,以抵消与癌症相关的适应性成本。然而,这种策略也有其局限性,如果癌症风险继续上升,它可能无法确保物种的可持续性。最后,一些物种可能会进化出更多的抗癌防御措施,这对它们的生物学和未来的进化路径会产生不确定的后果。总之,我们认为,接触致癌物质的增加对野生动物的影响是复杂的,从即时反应到长期进化变化,不一而足。我们迫切需要了解这些过程,尤其是在保护生物学的背景下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species

Growing evidence indicates that human activities are causing cancer rates to rise in both human and wildlife populations. This is due to the inability of ancestral anti-cancer defences to cope with modern environmental risks. The evolutionary mismatch between modern oncogenic risks and evolved cancer defences has far-reaching effects on various biological aspects at different timeframes, demanding a comprehensive study of the biology and evolutionary ecology of the affected species. Firstly, the increased activation of anti-cancer defences leads to excessive energy expenditure, affecting other biological functions and potentially causing health issues like autoimmune diseases. Secondly, tumorigenesis itself can impact important fitness-related parameters such as competitiveness, predator evasion, resistance to parasites, and dispersal capacity. Thirdly, rising cancer risks can influence the species' life-history traits, often favoring early reproduction to offset fitness costs associated with cancer. However, this strategy has its limits, and it may not ensure the sustainability of the species if cancer risks continue to rise. Lastly, some species may evolve additional anti-cancer defences, with uncertain consequences for their biology and future evolutionary path. In summary, we argue that the effects of increased exposure to cancer-causing substances on wildlife are complex, ranging from immediate responses to long-term evolutionary changes. Understanding these processes, especially in the context of conservation biology, is urgently needed.

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来源期刊
Evolutionary Applications
Evolutionary Applications 生物-进化生物学
CiteScore
8.50
自引率
7.30%
发文量
175
审稿时长
6 months
期刊介绍: Evolutionary Applications is a fully peer reviewed open access journal. It publishes papers that utilize concepts from evolutionary biology to address biological questions of health, social and economic relevance. Papers are expected to employ evolutionary concepts or methods to make contributions to areas such as (but not limited to): medicine, agriculture, forestry, exploitation and management (fisheries and wildlife), aquaculture, conservation biology, environmental sciences (including climate change and invasion biology), microbiology, and toxicology. All taxonomic groups are covered from microbes, fungi, plants and animals. In order to better serve the community, we also now strongly encourage submissions of papers making use of modern molecular and genetic methods (population and functional genomics, transcriptomics, proteomics, epigenetics, quantitative genetics, association and linkage mapping) to address important questions in any of these disciplines and in an applied evolutionary framework. Theoretical, empirical, synthesis or perspective papers are welcome.
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