Effect of single-photon emission computed tomography acquisition method and sampling angles on image quality and quantitative accuracy in xSPECT-reconstructed images.

Objective: The aim of this study was to evaluate the effects of the single-photon emission computed tomography (SPECT) acquisition method and sampling angles on the qualitative and quantitative interpretations of xSPECT-reconstructed images.

Methods: The spatial resolution was evaluated using a JSP phantom, and the uniformity and quantitative accuracy were verified with a NEMA IEC Body Phantom using an SIEMENS Symbia Intevo SPECT/computed tomography system. SPECT was performed using three acquisition methods (step-and-shoot, continuous, and acquire during the step), and the sampling angles were set to 2, 3, 4, 5, and 6°. The xSPECT-reconstruction technology which is used with ordered subset-conjugated gradient minimization was used for image reconstruction.

Results: Full width of half maximum, an evaluation index of spatial resolution, varied up to 2.73 mm with different sampling angles and up to 2.06 mm with different acquisition methods. Uniformity, as assessed by the coefficient of variation, improved with increasing sampling angles. The accuracy of the quantification of the hot sphere showed an error rate of approximately 10% depending on the sampling angle, and an error rate of approximately 5% depending on the different acquisition methods.

Conclusions: In xSPECT-reconstructed images, the difference in sampling angle has a greater impact on image quality and quantitativity than the difference in the acquisition method. For tests in which uniformity is important, a larger sampling angle is recommended.