过去三十年中犬利什曼病的全球流行情况:荟萃分析和系统综述。

IF 2 3区 农林科学 Q4 IMMUNOLOGY Comparative Immunology Microbiology and Infectious Diseases Pub Date : 2024-07-31 DOI:10.1016/j.cimid.2024.102211
Vito Priolo , Dorotea Ippolito , Kalú Rivas-Estanga , Chiara De Waure , Pamela Martínez-Orellana
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引用次数: 0

摘要

由幼年利什曼原虫引起的利什曼病是一种通过雌性沙蝇叮咬传播给人类和狗的人畜共患病媒传染病。家犬是主要的病原携带者,受感染的犬可能会出现或不出现临床症状。狗的感染率因研究人群、地理区域和采用的诊断方法而异。本研究旨在估算全球感染率,并根据各大洲、国家、诊断测试和选定的风险因素进行分组。从四个电子数据库中提取了估计婴儿利什曼原虫感染率的横断面研究(n=150;从 1990 年到 2020 年)。通过随机效应荟萃分析得出的汇总全球流行率为 15.2%(95 %CI 13.6-16.9),主要集中在农村地区(19.5%)和养狗地区(16.5%)。如果诊断是通过西部印迹(WB,32.9%)、细胞免疫测定(27.5%)、ELISA(17%)、PCR(16.9%)、IFAT(15.9%)、快速检测和直接凝集试验(DAT,11.5%)、细胞学/免疫组化(13.1%)和培养(8.6%)进行的,患病率则有所不同。研究偏差较小(P
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Canine leishmaniosis global prevalence over the last three decades: a meta-analysis and systematic review

Leishmaniosis by Leishmania infantum is a zoonotic vector-borne disease transmitted to humans and dogs by the bite of female sand-flies. The domestic dog is the main reservoir and infected dogs may show or not clinical symptoms. The prevalence of infection in dogs varies according to the population studied, the geographic area, and the diagnostics employed. This study aims to estimate the global prevalence, subgrouping per continent, country, diagnostic test and selected risk factors. Cross-sectional studies (n=150; from 1990 to 2020) estimating the prevalence of the infection by Leishmania infantum were extracted from four electronic databases. The pooled global prevalence obtained by random-effects meta-analysis was 15.2 % (95 %CI 13.6–16.9), mostly in rural (19.5 %) and owned dogs (16.5 %). Prevalence varied if the diagnosis was made by western blot (WB, 32.9 %), cellular immunity tests (27.5 %), ELISA (17 %), PCR (16.9 %), IFAT (15.9 %), rapid tests and direct agglutination test (DAT, 11.5 %), cytology/immunohistochemistry (13.1 %), culture (8.6 %). A small studies bias (P<0.005) in the overall prevalence meta-analysis, due to the impact of small-size studies on the overall results was found. Moreover, a continent-related bias was found regarding rapid test, DAT (P=0.021), and WB (P<0.001), as these assays are mainly used in South American studies. A study period bias (P=0.033) and a publication year bias (P=0.002) were detected for PCR, as the test was not employed before the year 2000. In conclusion, a high prevalence of canine leishmaniosis worldwide and high heterogeneity among studies were found.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
102
审稿时长
40 days
期刊介绍: Comparative Immunology, Microbiology & Infectious Diseases aims to respond to the concept of "One Medicine" and to provide a venue for scientific exchange. Based on the concept of "Comparative Medicine" interdisciplinary cooperation between specialists in human and animal medicine is of mutual interest and benefit. Therefore, there is need to combine the respective interest of physicians, veterinarians and other health professionals for comparative studies relevant to either human or animal medicine . The journal is open to subjects of common interest related to the immunology, immunopathology, microbiology, parasitology and epidemiology of human and animal infectious diseases, especially zoonotic infections, and animal models of human infectious diseases. The role of environmental factors in disease emergence is emphasized. CIMID is mainly focusing on applied veterinary and human medicine rather than on fundamental experimental research.
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