结构生物学告诉我们毒物的作用方式和检测方法。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-08-06 DOI:10.1146/annurev-pharmtox-061724-080642
Albane le Maire, William Bourguet
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引用次数: 0

摘要

研究化学物质对生物体的不良影响是一个古老而又紧张的研究领域。然而,长期以来,毒理学和环境健康科学一直以描述性方法为主,这些方法能够提供关联或相关性,但相对较少提供可靠的因果联系和分子机制。最近的成就表明,结构生物学方法可以为这一领域带来附加值。通过提供原子级别的信息,结构生物学是一种强大的工具,可用于破译毒物与细胞基本成分结合并改变其正常功能从而造成不良影响的机制。在此,我们将以干扰内分泌的化学物质为例,介绍基于结构了解其作用模式的最新进展,以及如何利用这些知识开发旨在预测大量化合物特性的计算工具。
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What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants.

The study of the adverse effects of chemical substances on living organisms is an old and intense field of research. However, toxicological and environmental health sciences have long been dominated by descriptive approaches that enable associations or correlations but relatively few robust causal links and molecular mechanisms. Recent achievements have shown that structural biology approaches can bring this added value to the field. By providing atomic-level information, structural biology is a powerful tool to decipher the mechanisms by which toxicants bind to and alter the normal function of essential cell components, causing adverse effects. Here, using endocrine-disrupting chemicals as illustrative examples, we describe recent advances in the structure-based understanding of their modes of action and how this knowledge can be exploited to develop computational tools aimed at predicting properties of large collections of compounds.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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