F127-folate@PLGA/CHL/IR780 纳米粒子对表达叶酸受体的癌细胞的治疗效果。

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Beilstein Journal of Nanotechnology Pub Date : 2024-07-31 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.78
Thi Ngoc Han Pham, Phuong-Thao Dang-Luong, Hong-Phuc Nguyen, Loc Le-Tuan, Xuan Thang Cao, Thanh-Danh Nguyen, Vy Tran Anh, Hieu Vu Quang
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引用次数: 0

摘要

集治疗和诊断功能于一体的热诊断平台因其潜在的优势而在药物研究领域备受关注。本研究报告了一种基于聚(ᴅ,ʟ-乳酸-共羟基乙酸)(PLGA)的新型多功能纳米颗粒载体系统的开发情况,该系统用于靶向递送化疗药物氯霉素(CHL)和成像药物 IR780。本研究的方法是在 PLGA 纳米粒子上加入 Pluronic F127-叶酸,从而实现向表达叶酸受体的癌细胞靶向递送。F127-叶酸@PLGA/CHL/IR780纳米粒子采用纳米沉淀技术配制而成,具有体积小、均匀度高、表面带负电荷等特点。重要的是,与叶酸受体阴性细胞(HEK 293)相比,叶酸靶向纳米颗粒在叶酸受体阳性癌细胞系(MCF-7 和 HepG-2)中表现出更强的吸收和细胞毒性。此外,与非靶向 F127@PLGA/CHL/IR780 纳米粒子相比,F127-叶酸@PLGA/CHL/IR780 纳米粒子对癌细胞的 IC50 值更低。这些研究结果表明,所开发的 F127-叶酸@PLGA/CHL/IR780 纳米粒子有望成为一种用于癌症靶向治疗和诊断的治疗诊断系统,充分利用了 PLGA、叶酸靶向以及治疗剂和成像剂整合的优势。
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Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells.

Theragnostic platforms, which integrate therapeutic and diagnostic capabilities, have gained significant interest in drug research because of to their potential advantages. This study reports the development of a novel multifunctional nanoparticle carrier system based on poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA) for the targeted delivery of the chemotherapeutic agent chlorambucil (CHL) and the imaging agent IR780. The approach in this study incorporates Pluronic F127-folate onto the PLGA nanoparticles, which enables targeted delivery to folate receptor-expressing cancer cells. The F127-folate@PLGA/CHL/IR780 nanoparticles were formulated using a nanoprecipitation technique, resulting in small size, high homogeneity, and negative surface charge. Importantly, the folate-targeted nanoparticles demonstrated enhanced uptake and cytotoxicity in folate receptor-positive cancer cell lines (MCF-7 and HepG-2) compared to folate receptor-negative cells (HEK 293). Additionally, the F127-folate@PLGA/CHL/IR780 nanoparticles exhibited a lower IC50 value against cancer cells than non-targeted F127@PLGA/CHL/IR780 nanoparticles. These findings suggest that the developed F127-folate@PLGA/CHL/IR780 nanoparticles hold promise as a theragnostic system for targeted cancer therapy and diagnosis, leveraging the advantages of PLGA, folate targeting, and the integration of therapeutic and imaging agents.

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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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