意义未定的单克隆丙种球蛋白病的无症状发病率和骨髓瘤诊断的临床前持续时间:模型研究。

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-06 DOI:10.1158/1055-9965.EPI-24-0490
Mengmeng Ji, Yi-Hsuan Shih, John H Huber, Mei Wang, Eric J Feuer, Ruth Etzioni, Shi-Yi Wang, Su-Hsin Chang
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引用次数: 0

摘要

背景意义未定的单克隆抗体病(MGUS)是多发性骨髓瘤(MM)的恶性前病变。由于缺乏对MGUS的人群筛查及其无症状的特性,MGUS的流行病学仍然未知。本研究估算了美国特定年龄和种族/人种的 MGUS 发病率以及从 MGUS 到 MM 的临床前持续时间。方法 采用先前发表的建模方法,利用 1999-2004 年全国健康与营养调查和 2000-2021 年监测、流行病学和最终结果中对 MGUS 患病率、MM 发病率、MM 特异性和全因死亡率以及人口年龄分布的估计,计算出全国 MGUS 发病率。用估计的 MGUS 患病率除以 MGUS 发病率,得出 MM 的临床前持续时间。结果 非西班牙裔白人(NHW)和非西班牙裔黑人(NHB)在50、60、70和80岁时的MGUS发病率分别为52、86、142和181/10万人年,非西班牙裔黑人为110、212、392和570/10万人年。NHW人群的平均临床前持续时间为20.5年(95%置信区间:16.5-26.1),NHB人群的平均临床前持续时间为14.2年(95%置信区间:11.5-17.6)。在 50-85 岁人群中,NHW人群罹患MGUS的累积风险为2.8%(95% CI:1.7%,4.2%),NHB人群为6.1%(95% CI:3.8%,10.0%)。结论 NHB人群在所有年龄段的MGUS发病率均高于NHW人群,且与NHW人群相比,MM的临床前持续时间较短。影响 本研究提供了有关 MGUS 流行病学的见解,并加深了我们对 MM 自然史的了解。
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Asymptomatic Incidence of Monoclonal Gammopathy of Undetermined Significance and Preclinical Duration to Myeloma Diagnosis: A Modeling Study.

Background Monoclonal gammopathy of undetermined significance (MGUS) is the premalignant condition of multiple myeloma (MM). Given a lack of population-based screening for MGUS and its asymptomatic nature, the epidemiology of MGUS remains unknown. This study estimated age- and race/ethnicity-specific MGUS incidence and preclinical duration from MGUS to MM in the United States. Methods A previously published modeling approach was used to calculate national MGUS incidence using estimates of MGUS prevalence, MM incidence, MM-specific and all-cause mortality, and population age distribution from the National Health and Nutrition Examination Survey, 1999-2004, and Surveillance, Epidemiology, and End Results, 2000-2021. The estimated MGUS prevalence was divided by MGUS incidence to obtain preclinical duration of MM. Results MGUS incidence for non-Hispanic white (NHW) populations was 52, 86, 142, and 181 and for non-Hispanic black (NHB) population was 110, 212, 392, and 570 per 100,000 person-years at ages 50, 60, 70, and 80, respectively. The average preclinical duration was 20.5 (95% confidence interval, CI: 16.5, 26.1) years for the NHW population and 14.2 (95% CI: 11.5, 17.6) years for the NHB population. The cumulative risk of developing MGUS in age 50-85 was 2.8% (95% CI: 1.7%, 4.2%) for the NHW population and 6.1% (95% CI: 3.8%, 10.0%) for the NHB population. Conclusion NHB populations had a higher MGUS incidence rate at all ages and a shorter preclinical duration of MM compared to their NHW counterparts. Impact This study provides insights into the epidemiology of MGUS and enhances our understanding of the natural history of MM.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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