与法尼醇有关的三氧化二铝矿物聚合体的理化特性和抗生物膜活性。

IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Brazilian oral research Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI:10.1590/1807-3107bor-2024.vol38.0066
Gabriela Mariana Castro-Núñez, Mário Tanomaru-Filho, Gisselle Moraima Chávez-Andrade, Fernanda Ferrari Esteves Torres, Roberta Bosso-Martelo, Juliane Maria Guerreiro-Tanomaru
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引用次数: 0

摘要

本研究评估了含有 1% 或 2% 法呢醇的白色三氧化二铝矿物骨料 (MTA) 的理化特性和抗生物膜特性。根据 ISO 6876/2012 标准对固化时间进行了评估。pH值在 1、3、7、14、21 和 28 天后进行评估。在蒸馏水中浸泡后,对水门汀的溶解度(质量损失百分比)和体积变化(通过显微 CT)进行了评估。使用显微 CT 评估了材料内部是否存在空隙。对粪肠球菌的抗生物膜活性是通过水晶紫测定法和改良的直接接触试验进行评估的,生物膜是在牛根牙本质上形成的,持续时间为 14 天。数据采用方差分析/Tukey 检验,显著性水平为 5%。在 MTA 中加入法尼醇可增加其凝固时间,但会降低其 30 天后的溶解度以及在所有时间段内的体积损失(p < 0.05)。各种材料在 7 天后的放射性和可溶性相似(p > 0.05)。法呢醇在 1 天和 3 天后的 pH 值最高(p < 0.05)。法尼醇与 MTA 的结合促进了空隙的减少,并提高了对粪大肠杆菌生物膜生物量的抗菌活性(p < 0.05)。总之,添加法呢醇可改善 MTA 的抗菌性能和稠度。
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Physicochemical properties and antibiofilm activity of mineral trioxide aggregate associated with farnesol.

This study assessed the physicochemical and antibiofilm properties of white mineral trioxide aggregate (MTA) associated with 1 or 2% of farnesol. Setting time was evaluated based on ISO 6876/2012. Radiopacity was evaluated by radiographic analysis. pH was assessed after time intervals of 1, 3, 7, 14, 21, and 28 days. Solubility (% mass loss) and volumetric change (by micro-CT) of the cements were evaluated after immersion in distilled water. The presence of voids inside the materials was assessed by using micro-CT. Antibiofilm activity against Enterococcus faecalis was evaluated by crystal violet assay and the modified direct contact test performed with biofilm previously formed on bovine root dentin for 14 days. Data were submitted to ANOVA/Tukey tests with 5% significance level. The incorporation of farnesol into MTA increased its setting time, but decreased its solubility at 30 days and its volumetric loss in all periods (p < 0.05). Radiopacity and solubility after 7 days were similar among the materials (p > 0.05). The association of farnesol showed the highest pH value after 1 and 3 days (p < 0.05). The association of farnesol with MTA promoted a decrease in the presence of voids, and increased the antimicrobial activity on biofilm biomass of E. faecalis (p < 0.05). In conclusion, the addition of farnesol can be suggested to improve the antimicrobial properties and the consistency of MTA.

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来源期刊
CiteScore
3.70
自引率
4.00%
发文量
107
审稿时长
12 weeks
期刊最新文献
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