Brazilian oral research最新文献

The objective of this study was to assess the impact of root canal treatment (RCT) in single-rooted teeth with asymptomatic apical periodontitis on oral health-related quality of life (OHRQoL). As a secondary objective, the impact of factors such as age, gender, ethnicity, tooth groups, arch position, crown destruction, postoperative pain, edema, and use of analgesics after procedure were also noted. A prospective cohort study was designed and enrolled in a sample of 105 patients who needed root canal treatment in single-rooted maxillary or mandibular teeth with asymptomatic apical periodontitis, without preoperative symptoms. RCT was performed in one session. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) at baseline and after seven and 30 days. Predictor variables were also collected: age, gender, ethnicity, tooth groups, arch position, destruction of the crown, postoperative pain, edema, and the use of analgesics. Data were tabulated and analyzed in SPSS software, with alpha value set at 0.05. All domains of the OHIP-14 questionnaire revealed a statistically significant difference between the times evaluated (p < 0.001), showing the positive impact of the RCT on OHRQoL, with moderate and large effects. There was a significant difference in the total score for gender (p = 0.001), ethnicity (p = 0.010), and crown destruction (p = 0.002). RCT improved OHRQoL scores in all domains assessed by OHIP-14, with moderate and large effects. Factors such as female gender, mixed race and afrodescendant participants, and extensive crown destruction negatively influenced the OHRQoL of patients pre-RCT.

Assess the association between dental caries clinical stage, lesion location, and oral health-related quality of life (OHRQoL) in preschool children. A cross-sectional study was conducted with a representative sample of 643 caregiver-child dyads aged 0-5 years. Children underwent oral examinations using the International Caries Detection and Assessment System (ICDAS) and the International Caries Classification and Management System (ICCMS™) criteria to classify caries stage and lesion location. Traumatic dental injuries (TDI) were assessed using Andreasen's classification. Caregivers completed the Early Childhood Oral Health Impact Scale (ECOHIS). Weighted Kappa coefficients assessed intra- and inter-examiner reliability. Negative binomial regression models, adjusted for sociodemographic variables and clinical factors, estimated the association between caries stage/location and ECOHIS scores. The prevalence of dental caries (all stages) was 72.6%, with 27.3% of children caries-free. Overall, 48.2% of caregivers reported at least one oral health impact in their child's life (ECOHIS ≥ 1). Children with extensive lesions (stage C) had significantly worse total and domain ECOHIS scores than caries-free children (p < 0.001), regardless of lesion location. Moderate lesions (stage B) affected OHRQoL only when present in both anterior and posterior teeth (RR = 1.54; p = 0.045). Older age, public school attendance, and household crowding were also associated with poorer OHRQoL. The presence of TDI was independently associated with poorer OHRQoL (RR = 1.63; p < 0.001). These findings highlight the need for targeted, patient-centred interventions to address caries burden effectively.

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck. Studies on the inflammatory pathways that have evolved during the development of the disease remain controversial. We assessed the expression of inflammatory markers, such as COX (cyclooxygenase)-2, CD68, CD4, and tumor necrosis factor (TNF)-α, based on prognostic variables and disease-specific survival in patients with OSCC. Immunohistochemical analysis of COX-2, TNF-α, CD4, and CD68 was conducted in 72 patients treated surgically. Neural invasion was evaluated based on S100 expression. Disease-specific survival was assessed using Cox regression analysis. Most participants were male, with a mean age of 61 years. A total of 77.5% of patients presented with clinical stages III-IV, and 70% underwent surgery combined with radiotherapy or chemotherapy. The expression of CD68, CD4, and TNF-α was not associated with clinical variables or tumor differentiation. COX-2 expression correlated with tumor size (p = 0.01), whereas high TNF-α expression was noted in moderately/poorly differentiated OSCC. The absence of nodal involvement (hazard ratio [HR]: 0.47, confidence interval [CI]: 0.25-0.87, p = 0.001) was linked to lower death risk, whereas surgery without adjuvant radiotherapy or chemotherapy was associated with a higher risk of death (HR: 2.09, 95%CI: 1.02-4.27, p = 0.043). Multivariate analysis revealed that high COX-2 expression predicted a shorter disease-specific survival. Altogether, high TNF-α expression is prevalent in moderately/poorly differentiated OSCC, and elevated COX-2 expression correlates with larger tumor size and poorer survival in OSCC.

This study aimed to identify factors associated with dental pain among schoolchildren in Diamantina, Minas Gerais, Brazil. A total of 627 children aged 8-11 years were assessed through questionnaires and clinical examinations in both public and private schools. We employed a complex, probabilistic, two-stage cluster sampling method involving schools and classes. The sample size was calculated assuming a 50% prevalence of events or diseases, a 95% confidence level, a 5.0% margin of error, a design effect (deff) of 1.5, and a 15% non-response rate. The dependent variable, dental pain, was assessed by asking: "Have you ever had a toothache in your life?" with possible responses of "No" or "Yes." The independent variables included sociodemographic factors and dental history. Binary logistic regression was used to estimate the odds ratio (OR). Approximately 70.6% of the children reported having experienced dental pain at least once in their lives. In the final model, the likelihood of having experienced dental pain was higher among children who had either deciduous or permanent teeth restored (OR = 1.99; 95%IC: 1.19-3.29), who had a normative need for dental treatment (OR = 3.00; 95%IC: 1.96-4.58), and whose guardians perceived their oral health negatively (OR = 1.81; 95%IC: 1.19-2.75). Dental pain is a significant oral health issue among children. This pain was associated with both unfavorable normative assessments and subjective perceptions of oral health, underscoring the importance of preventive and promotive strategies for children's oral health.

The aim of this systematic literature review and meta-analysis was to answer the following research question: "Is sugar consumption associated with early childhood caries among children under 6 years of age in cohort studies?". The following electronic databases were accessed from December 2020 to May 2025 to identify the existing literature: Bireme, Pubmed/Medline, Scielo, Scopus, and Web of Science. Studies considered eligible for this systematic review were those that investigated sugar consumption as the main exposure and early childhood caries (ECC) as the outcome. Study selection and data extraction were performed independently by two reviewers. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist for cohort studies scale. The search strategy retrieved 718 studies. After title and abstract screening, 59 were selected for full-text review, leading to the inclusion of 17 original studies in this systematic review. Finally, nine studies provided sufficient data for a meta-analysis. The association between sugar consumption and ECC was consistent across most of the cohort studies included in this review, which reported that higher sugar consumption was associated with higher prevalence of dental caries. The pooled effect estimate from the meta-analysis yielded an OR of 1.59 and a 95% CI (1.50-1.68), indicating that children who consumed sugar in early childhood were 59% more likely to develop caries compared to those who did not consume sugar. The included studies had a low risk of bias. Our systematic review and meta-analysis confirmed the association between sugar consumption and ECC in longitudinal cohort studies.

To evaluate the pH, solubility and intratubular disinfection of the bioceramic intracanal drug Bio-C® Temp (BCT), calcium hydroxide-based paste Calen® (CAL) and their associations in different proportions: BCT 75% + CAL 25%; BCT 50% + CAL 50%; BCT 25% + CAL 75%. Polyethylene tubes containing the medication, were used. The pH was evaluated after 1, 3, 7, 14 and 21 days and solubility after 14 days. Bovine dentin tubes were contaminated with Enterococcus faecalis to assess intratubular disinfection by using confocal laser scanning microscopy and use of Live/Dead BacLight Bacterial stain. Data were submitted to statistical tests of normality, then ANOVA and Tukey (α = 0.05). BCT showed a lower pH after 3 and 14 days (p < 0.05). CAL had the highest pH at all time intervals (p > 0.05). CAL and associations with BCT showed greater weight loss (p < 0.05). BCT showed intratubular disinfection similar to that of BCT/CAL 25% (p > 0.05). CAL and BCT/CAL at 50% and 75% were similar and had the highest intratubular disinfection values (p > 0.05). Combinations of Bio-C® Temp with 50% or more calcium hydroxide paste provide higher alkalinization, solubility and intratubular disinfection values of the bioceramic medication, favoring its potential for clinical application.

Oral health literacy (OHL) may play a crucial role for managing traumatic dental injuries. In this pre-post study, the effect of the different dimensions of OHL on the efficacy of using an information leaflet (IL for managing permanent tooth avulsion ) was assessed in elementary schoolteachers. Functional OHL was measured using the Brazilian version of the Rapid Estimate of Adult Literacy in Dentistry (BREALD-30), while interactive OHL was assessed with the Oral Health Literacy Adult Questionnaire (BOHL-AQ). Knowledge scores (KS) on avulsion management were collected at three intervals: before reading the IL (baseline), immediately post-intervention (Phase I), and 60 days post-intervention (Phase II). The effect on OHL was assessed by comparing KS means between Phase I/Baseline (acquisition) and Phases II/I (retention). Participants with high OHL/BOHL had a greater difference in mean KS values between Phase I/baseline, while those with high OHL/BREALD-30 showed a smaller difference between phases II/I. Different dimensions of OHL impacted the effectiveness of an educational intervention on managing permanent tooth avulsion with use of a leaflet.

The aim of this study was to assess the biosafety practices adopted during the COVID-19 pandemic that persisted in post-pandemic orthodontic clinical routines. In this cross-sectional study, 722 Brazilian orthodontists who were in the early phase of the pandemic, and 203 from the later phase, respectively, answered a 45-item questionnaire addressing basic personal information, use of personal protective equipment, biosafety protocols, and COVID-19 incidence. Descriptive statistics and chi-square tests were used to analyze the data. Most participants were infected with the coronavirus (from 10.1% to 65%). While 52.4% perceived providing care as very risky during the pandemic, this perception shifted to decreased to a moderate level of risk in the late phase of the pandemic (40.4%). The use of protective face masks/face shields decreased from 51.7% to 25.1%, as well as the use of disposable coats (from 77.1% to 45.8%). Many orthodontists discontinued the use of PFF2/N95 masks and reverted to wearing surgical masks again. Most orthodontists disinfected orthodontic bands, and photographic retractors through manual washing and autoclaving. Most participants preferred to clean their orthodontic pliers with 70% alcohol. A decline in orthodontists' concern about biosafety during clinical appointments was observed in the late phase of the pandemic. Moreover, the need for greater specific care still persists, especially regarding the proper use of disposable coats, face shields, and surgical masks.

Metrics derived from online social platforms indicate current interest in a specific topic. This study aimed to analyze the characteristics and social interest in scientific publications on bruxism using an altmetric analysis. A search was conducted in August 2024 in the Dimensions database. The following data were extracted: altmetric attention score (AAS), citations, year, language, access type, study design, topic (general objective and age group), journal, country, institution, and authors. VOSviewer was used to generate collaborative networks, whereas Google Trends was consulted to assess public interest in bruxism-related research. A Spearman correlation analysis was performed to establish the relationship between AAS and citations. A total of 196 studies published between 1992 and 2024 were included. The most widely accessed study had an AAS of 393. Significant interest in bruxism was observed among Mendeley, news outlets, and X users. Most studies were observational (n = 99), addressing the etiologic factors of bruxism (n = 75) and focusing primarily on the adult population (n = 148). The Journal of Oral Rehabilitation stood out as the most relevant journal (n = 36). Most articles were published in Brazil (n = 40), and Lobbezoo was the most frequent author (n = 27). VOSviewer revealed significant collaborations among authors. Most studies were not openly accessible (n = 105). A very weak positive correlation (r = 0.042) was observed between AAS and the number of citations. This study highlighted a social interest in scientific publications on bruxism, particularly those addressing etiologic factors.

The objective of this study was to develop a bioabsorbable membrane composed of poly(butylene adipate-co-terephthalate) (PBAT) with alkyl trimethyl ammonium bromide (ATAB) to provide antimicrobial properties. Membranes were manufactured via the solvent casting technique using chloroform solutions containing PBAT and varying concentrations of ATAB (1, 2.5, and 5% wt), with ATAB-free membranes as a control. The characterization of the membranes included assessments of contact angle, surface free energy, and degradation in distilled water over periods of one week, one month, and three months. Mechanical properties were evaluated via tensile strength, and changes in water pH were monitored from 24 hours to three months post-immersion. Cytotoxicity was assessed using gingival fibroblasts and pre-osteoblasts via the SRB assay. Antimicrobial activity was tested against Staphylococcus aureus. ATAB inclusion reduced water contact angle and increased surface free energy compared to controls (p < 0.001). The addition of 5% wt ATAB decreased the tensile strength of PBAT membranes. At one month, a reduced mass was observed for the 2.5% wt ATAB membrane. The specimens' mass was reduced for all groups after three months of immersion in water in comparison to the initial measurement, while a reduction in thickness was found in all time points, without the influence of ATAB. ATAB incorporation reduced cell viability. Antimicrobial efficacy, resulting in a > 3 log10 bacterial reduction, was observed for S. aureus at the 5% wt concentration. The addition of 2.5% wt ATAB to PBAT membranes may be a suitable strategy to generate barrier membranes with an antibacterial effect while maintaining acceptable mechanical and surface properties.