短链脂肪酸在心肌缺血再灌注损伤中的作用

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI:10.1007/s13668-024-00564-6
Xunxun Wang, Yalan Dong, Renyin Huang, Fang Wang, Junke Xie, Hui Liu, Yan Wang, Yi Wang, Shanshan Luo, Desheng Hu
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引用次数: 0

摘要

综述目的:本研究旨在回顾短链脂肪酸(SCFAs)在调节心肌缺血再灌注损伤(MIRI)方面的作用:众所周知,冠心病(CHD)是导致全球死亡和残疾的主要原因。由于心肌缺血再灌注损伤期间能量生产的突然转变,心脏底物代谢在评估心脏损伤的严重程度方面起着决定性作用。脂肪酸是心脏的主要能量燃料,按碳链长度可分为长链脂肪酸、中链脂肪酸和短链脂肪酸。SCFAs 是富含纤维的膳食在厌氧细菌发酵过程中产生的主要代谢产物,以前曾被证明对脑血管疾病有保护作用。同时,越来越多的证据表明,SCFAs 在心脏能量代谢中也能发挥重要作用。多项研究结果表明,SCFAs 具有抗炎、抗发炎、连接肠道-大脑神经回路和调节肠道菌群等保护心脏的作用。
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The Role of Short-Chain Fatty Acids in Myocardial Ischemia-Reperfusion Injury.

Purpose of review: This study aims to review the effects of short-chain fatty acids (SCFAs) in regulating the myocardial ischemia-reperfusion injury (MIRI).

Recent findings: Coronary heart disease (CHD) is a well-known leading cause of death and disability worldwide. Cardiac substrate metabolism plays the determinant role in assessing the severity of heart injury due to the abruptly shifted energy production during the MIRI. Fatty acids are the main energy fuels for the heart, which are classified into long-, medium- and short chain fatty acids by the length of carbon chain. SCFAs are the main metabolites derived from the anaerobic bacterial fermentation of fiber-rich diets, which are shown to play a protective role in cerebrovascular disease previously. Meanwhile, accumulating evidences suggest that SCFAs can also play a crucial role in cardiac energy metabolism. Results of various studies revealed the cardioprotective effects of SCFAs by displaying anti-inflammatory and anti-ferroptotic function, connecting gut-brain neural circuit and regulating the intestinal flora.

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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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