{"title":"染色体生物学：大而不能倒","authors":"Natalie J Nannas","doi":"10.1016/j.cub.2024.06.047","DOIUrl":null,"url":null,"abstract":"<p><p>Spindles are microtubule-based machines that segregate chromosomes during cell division. Spindle morphology and dynamics are malleable based on forces within the spindle, and a new study reveals the extreme plasticity of the Saccharomyces cerevisiae spindle to adapt and segregate engineered mega-chromosomes.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chromosome biology: Too big to fail.\",\"authors\":\"Natalie J Nannas\",\"doi\":\"10.1016/j.cub.2024.06.047\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Spindles are microtubule-based machines that segregate chromosomes during cell division. Spindle morphology and dynamics are malleable based on forces within the spindle, and a new study reveals the extreme plasticity of the Saccharomyces cerevisiae spindle to adapt and segregate engineered mega-chromosomes.</p>\",\"PeriodicalId\":11359,\"journal\":{\"name\":\"Current Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2024-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cub.2024.06.047\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cub.2024.06.047","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Spindles are microtubule-based machines that segregate chromosomes during cell division. Spindle morphology and dynamics are malleable based on forces within the spindle, and a new study reveals the extreme plasticity of the Saccharomyces cerevisiae spindle to adapt and segregate engineered mega-chromosomes.
期刊介绍：
Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.
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