泛免疫炎症值与牙周炎之间的 U 型关系Nhanes 2009-2014。

IF 3.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of periodontology Pub Date : 2024-08-06 DOI:10.1002/JPER.24-0318

Huan Zhou, Shusen Zhang, Di Miao, Ruoyan Cao

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引用次数: 0

摘要

背景：本研究旨在通过全国性大型调查，研究泛免疫炎症值（PIV）与牙周炎之间的关系：本研究旨在基于一项大型全国性调查，探讨泛免疫炎症值（PIV）与牙周炎之间的关系：本横断面研究的数据来自 2009-2014 年全国健康与营养调查（NHANES），共有 10,300 名参与者。牙周炎的分类基于 2017 年的分类方案。PIV 用公式确定：(中性粒细胞计数×单核细胞计数×血小板计数）/淋巴细胞计数。采用限制性三次样条分析和加权多变量逻辑回归分析来评估PIV与牙周炎之间的关联：结果：PIV 与 III/IV 期牙周炎的关系呈 U 型（Pnon-linearity Q4vs2 = 1.72，95% CI：1.36-2.18），与高血压患者（ORQ4vs2 = 1.78，95% CI：1.38-2.28）的关系呈显著的交互作用（Pinteraction 结论：PIV 与牙周炎的关系呈 U 型，与高血压患者（ORQ4vs2 = 1.78，95% CI：1.38-2.28）的关系呈显著的交互作用（Pinteraction）：PIV与III/IV期牙周炎之间存在U型关系，这表明PIV可能是牙周炎的一种辅助治疗策略。在男性和高血压患者中，较高的 PIV 值与 III/IV 期牙周炎的相关性更强。白话摘要：美国成年人的泛免疫炎症值与牙周炎之间存在 U 型关联，表明保持适度的免疫炎症反应对牙周健康至关重要。

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U-shaped association between pan-immune-inflammation value and periodontitis: NHANES 2009–2014

Background

This study aimed to investigate the relationship between the pan-immune-inflammation value (PIV) and periodontitis based on a large national survey.

Methods

In the present cross-sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.

Results

The associations between PIV and stage III/IV periodontitis followed a U-shaped pattern (P_{non-linearity} < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01–1.46), third quartile (OR = 1.34; 95% CI: 1.11–1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25–1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (OR_Q4vs2 = 1.72, 95% CI: 1.36–2.18) and individuals with hypertension (OR_Q4vs2 = 1.78, 95% CI: 1.38–2.28) with significant interactions (P_interaction < 0.05).

Conclusions

There is a U-shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.

Plain Language Summary

A U-shaped association exists between the pan-immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.

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