心肌细胞的分区调节肌酸激酶和腺苷酸激酶的活性。

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-08-07 DOI:10.1002/1873-3468.14994
Rikke Birkedal, Jelena Branovets, Marko Vendelin
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引用次数: 0

摘要

细胞内分子由运动蛋白运输,或通过分子随机运动产生的扩散进行移动。心肌细胞内充满了对功能至关重要的结构,但同时也限制了扩散空间,为细胞提供了控制扩散的手段。它们形成了局部浓度不同于整体平均浓度的区室。例如,钙和环磷酸腺苷被高度区隔,使这些多功能的第二信使能够根据不同的位置发出不同的信号。在能量分区中,AMP 和 ADP 与 ATP 的比例与平均比例不同。这对促进心脏兴奋-收缩耦合和机械功的 ATP 酶的性能非常重要。最近的一项研究表明,分区可在原位调节肌酸激酶和腺苷酸激酶的活性。这可能会对通过 AMP 激活激酶等传递能量信号产生影响。这凸显了我们在解释细胞生理学时考虑区隔的重要性,并开发了评估 AMP 和 ADP 局部浓度的方法,以加深我们对不同类型细胞中区隔的理解。
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Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities.

Intracellular molecules are transported by motor proteins or move by diffusion resulting from random molecular motion. Cardiomyocytes are packed with structures that are crucial for function, but also confine the diffusional spaces, providing cells with a means to control diffusion. They form compartments in which local concentrations are different from the overall, average concentrations. For example, calcium and cyclic AMP are highly compartmentalized, allowing these versatile second messengers to send different signals depending on their location. In energetic compartmentalization, the ratios of AMP and ADP to ATP are different from the average ratios. This is important for the performance of ATPases fuelling cardiac excitation-contraction coupling and mechanical work. A recent study suggested that compartmentalization modulates the activity of creatine kinase and adenylate kinase in situ. This could have implications for energetic signaling through, for example, AMP-activated kinase. It highlights the importance of taking compartmentalization into account in our interpretation of cellular physiology and developing methods to assess local concentrations of AMP and ADP to enhance our understanding of compartmentalization in different cell types.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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