氧化应激与衰老：与年龄相关疾病的协同作用。

IF 3.5 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-08-07 DOI:10.1002/1873-3468.14995

Daniela F. Santos, Sónia Simão, Clévio Nóbrega, José Bragança, Pedro Castelo-Branco, Inês M. Araújo, ALFA Score Consortium

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引用次数: 0

摘要

衰老的特点是生理功能逐渐衰退，并导致多种残疾，包括细胞和组织对病理性氧化应激的敏感性增加。近年来，人们一直在努力更好地理解年龄与氧化应激之间的关系，并进一步开发治疗策略，以尽量减少这两种事件对老年相关疾病的影响。在这项工作中，我们回顾了氧化剂和抗氧化剂系统在衰老和疾病发展过程中的影响，并讨论了氧化应激和其他衰老过程的相互影响，重点是在老年人群中开展的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oxidative stress and aging: synergies for age related diseases

Aging is characterized by a progressive decline in physiological function and underlies several disabilities, including the increased sensitivity of cells and tissues to undergo pathological oxidative stress. In recent years, efforts have been made to better understand the relationship between age and oxidative stress and further develop therapeutic strategies to minimize the impact of both events on age-related diseases. In this work, we review the impact of the oxidant and antioxidant systems during aging and disease development and discuss the crosstalk of oxidative stress and other aging processes, with a focus on studies conducted in elderly populations.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.