Yuan-Xia Zhou , Feng-Qian Liu , Guo-Qin Wang , Dan Yang , Pan Han , Lin-Hai Jing
{"title":"无金属条件下光氧化催化 3-亚甲基异吲哚啉-1-酮的 C(sp2)-H 三氟甲基化反应。","authors":"Yuan-Xia Zhou , Feng-Qian Liu , Guo-Qin Wang , Dan Yang , Pan Han , Lin-Hai Jing","doi":"10.1039/d4ob01046a","DOIUrl":null,"url":null,"abstract":"<div><p>A facile synthetic method for direct C(sp<sup>2</sup>)–H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photoredox-catalyzed C(sp2)–H trifluoromethylation of 3-methylene-isoindolin-1-ones under metal-free conditions†\",\"authors\":\"Yuan-Xia Zhou , Feng-Qian Liu , Guo-Qin Wang , Dan Yang , Pan Han , Lin-Hai Jing\",\"doi\":\"10.1039/d4ob01046a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A facile synthetic method for direct C(sp<sup>2</sup>)–H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1477052024006906\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024006906","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Photoredox-catalyzed C(sp2)–H trifluoromethylation of 3-methylene-isoindolin-1-ones under metal-free conditions†
A facile synthetic method for direct C(sp2)–H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.
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