Nrf2 是能量代谢和线粒体功能的调节器。

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-08-08 DOI:10.1002/1873-3468.14993
Alina Luchkova, Ana Mata, Susana Cadenas
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引用次数: 0

摘要

核因子红细胞-2相关因子2(Nrf2)对控制细胞氧化还原平衡至关重要。激活后,Nrf2 通过表达多个编码抗氧化和解毒酶的基因,产生细胞保护作用。Nrf2 还能通过磷酸戊糖途径增加 NADPH 的可用性以再生谷胱甘肽,从而提高抗氧化防御能力。微阵列和全基因组定位分析发现了许多 Nrf2 靶基因,而不是那些与其氧化还原调节能力有关的基因。Nrf2 调节多个中间代谢途径,并参与癌细胞代谢重编程,从而导致恶性表型。Nrf2 还能调节线粒体呼吸的底物利用。在此,我们回顾了支持 Nrf2 在能量代谢和线粒体功能调节中发挥重要作用的实验证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nrf2 as a regulator of energy metabolism and mitochondrial function

Nuclear factor erythroid-2-related factor 2 (Nrf2) is essential for the control of cellular redox homeostasis. When activated, Nrf2 elicits cytoprotective effects through the expression of several genes encoding antioxidant and detoxifying enzymes. Nrf2 can also improve antioxidant defense via the pentose phosphate pathway by increasing NADPH availability to regenerate glutathione. Microarray and genome-wide localization analyses have identified many Nrf2 target genes beyond those linked to its redox-regulatory capacity. Nrf2 regulates several intermediary metabolic pathways and is involved in cancer cell metabolic reprogramming, contributing to malignant phenotypes. Nrf2 also modulates substrate utilization for mitochondrial respiration. Here we review the experimental evidence supporting the essential role of Nrf2 in the regulation of energy metabolism and mitochondrial function.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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