2007年至2022年法国献血者梅毒检测情况。

IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Eurosurveillance Pub Date : 2024-08-01 DOI:10.2807/1560-7917.ES.2024.29.32.2400036
Syria Laperche, Claire Sauvage, Sophie Le Cam, Florence Lot, Lucile Malard, Pierre Gallian, Elodie Pouchol, Pascale Richard, Pascal Morel, Philippe Grange, Pierre Tiberghien, Nadjet Benhaddou, Nicolas Dupin
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History of syphilis was obtained at the post-donation interview or based on serology results for repeat donors.ResultsUntil 2021, positivity rates remained stable (mean: 1.18/10,000 donations, range: 1.01-1.38). An increased rate was observed in 2022 (1.74/10,000; p = 0.02). Over the whole study period, prevalence was 2.2 times higher in male than in female BD (4.1 times higher in 2022). The proportion of males with an identified risk factor who have sex with men increased from 16.7% in 2007 to 64.9% in 2022. Based on NTT, 79 (18%) of the donors who were seropositive in 2022 were classified as having been infected in the previous year. History of syphilis was available for 30 of them. All had an infection within the previous 3 years. Among seven donors with a syphilis < 12 months before testing, one had an NTT titre ≥ 8, three a titre between 1 and 4, three were negative.ConclusionSyphilis seropositivity increased considerably in BDs in 2022, mostly in males, notably MSM. 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引用次数: 0

摘要

背景在许多国家,献血者(BD)的梅毒感染率都在上升。目的我们旨在描述法国BD梅毒血清阳性率的变化趋势,确定风险因素,并评估非抗梅毒试验(NTT)能否确定BD梅毒痊愈时间是否超过1年。方法分析涵盖2007年至2022年期间的45,875,939次献血。在2022年梅毒阳性的474名BD中,有429人接受了NTT的进一步检查。梅毒病史是在捐献后访谈中获得的,或根据血清学结果对重复捐献者进行调查。结果直到2021年,阳性率保持稳定(平均:1.18/10,000次捐献,范围:1.01-1.38)。2022 年,阳性率有所上升(1.74/10,000;P = 0.02)。在整个研究期间,男性 BD 患病率是女性的 2.2 倍(2022 年为 4.1 倍)。具有已确定风险因素的男性同性性行为者比例从 2007 年的 16.7% 上升到 2022 年的 64.9%。根据 NTT,在 2022 年血清反应呈阳性的捐献者中,有 79 人(18%)被归类为在上一年感染过梅毒。其中 30 人有梅毒史。所有捐献者都在过去 3 年内感染过梅毒。在 7 名梅毒捐献者中
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Syphilis testing in blood donors, France, 2007 to 2022.

BackgroundSyphilis in blood donors (BD) has increased in many countries.AimWe aimed to describe trends in syphilis seroposivity in BD in France, to identify risk factors and assess if a non-treponemic test (NTT) could define BD having recovered from syphilis for more than 1 year.MethodsThe analysis covered the period 2007 to 2022 and 45,875,939 donations. Of the 474 BD syphilis-positive in 2022, 429 underwent additional investigations with an NTT. History of syphilis was obtained at the post-donation interview or based on serology results for repeat donors.ResultsUntil 2021, positivity rates remained stable (mean: 1.18/10,000 donations, range: 1.01-1.38). An increased rate was observed in 2022 (1.74/10,000; p = 0.02). Over the whole study period, prevalence was 2.2 times higher in male than in female BD (4.1 times higher in 2022). The proportion of males with an identified risk factor who have sex with men increased from 16.7% in 2007 to 64.9% in 2022. Based on NTT, 79 (18%) of the donors who were seropositive in 2022 were classified as having been infected in the previous year. History of syphilis was available for 30 of them. All had an infection within the previous 3 years. Among seven donors with a syphilis < 12 months before testing, one had an NTT titre ≥ 8, three a titre between 1 and 4, three were negative.ConclusionSyphilis seropositivity increased considerably in BDs in 2022, mostly in males, notably MSM. Available data did not allow appropriate evaluation of the NTT to distinguish recent from past infection.

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来源期刊
Eurosurveillance
Eurosurveillance INFECTIOUS DISEASES-
CiteScore
32.70
自引率
2.10%
发文量
430
审稿时长
3-8 weeks
期刊介绍: Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.
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