患有慢性肾病的老年人的身体功能和死亡率。

IF 8.5 1区 医学 Q1 UROLOGY & NEPHROLOGY Clinical Journal of the American Society of Nephrology Pub Date : 2024-10-01 Epub Date: 2024-08-08 DOI:10.2215/CJN.0000000000000515
Christine K Liu, Gomathy Parvathinathan, Margaret R Stedman, Stephen L Seliger, Daniel E Weiner, Manjula Kurella Tamura
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引用次数: 0

摘要

背景:准确的死亡率预测可以为患有慢性肾脏病(CKD)的老年人的临床治疗提供指导。然而,现有的工具并未将身体功能纳入其中,而身体功能是老年人死亡的独立预测因素。我们确定了纳入身体功能测量是否能改善慢性肾脏病老年人的死亡率预测:我们纳入了年龄≥65 岁、具有估计肾小球滤过率(eGFR)的慢性肾功能不全队列参与者:2 338 人中,平均年龄为 70±4 岁;43% 为女性,43% 为黑人。平均 eGFR 为 42±13 mL/min/1.73m2,尿白蛋白-肌酐比值中位数为 33 mg/g[Q1 9,Q3 206]。中位随访期为 5 年,其中 392 人死亡,164 人发展为 KFRT。在删减分析中,增加步态速度或虚弱程度可提高死亡率风险预测。步态速度评分的 C 统计量从 0.69 变为 0.72,虚弱评分的 C 统计量从 0.70 变为 0.73。在非删失分析中,步速或虚弱模型的表现相似:结论:在患有慢性肾脏病的老年人中,增加身体功能测量可适度改善死亡率预测。
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Physical Function and Mortality in Older Adults with Chronic Kidney Disease.
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来源期刊
CiteScore
12.20
自引率
3.10%
发文量
514
审稿时长
3-6 weeks
期刊介绍: The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.
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