胆汁酸调节受体免疫学

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2024-07-01 DOI:10.1016/j.plipres.2024.101291
Stefano Fiorucci , Silvia Marchianò , Ginevra Urbani , Cristina Di Giorgio , Eleonora Distrutti , Angela Zampella , Michele Biagioli
{"title":"胆汁酸调节受体免疫学","authors":"Stefano Fiorucci ,&nbsp;Silvia Marchianò ,&nbsp;Ginevra Urbani ,&nbsp;Cristina Di Giorgio ,&nbsp;Eleonora Distrutti ,&nbsp;Angela Zampella ,&nbsp;Michele Biagioli","doi":"10.1016/j.plipres.2024.101291","DOIUrl":null,"url":null,"abstract":"<div><p>Bile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from cholesterol metabolism, secondary bile acids represent the products of microbial enzymes. Close to 100 different enzymatic modifications of bile acids structures occur in the human intestine and clinically guided metagenomic and metabolomic analyses have led to the identification of an extraordinary number of novel metabolites. These chemical mediators make an essential contribution to the composition and function of the postbiota, participating to the bidirectional communications of the intestinal microbiota with the host and contributing to the architecture of intestinal-liver and -brain and -endocrine axes. Bile acids exert their function by binding to a group of cell membrane and nuclear receptors collectively known as bile acid-regulated receptors (BARRs), expressed in monocytes, tissue-resident macrophages, CD4+ T effector cells, including Th17, T regulatory cells, dendritic cells and type 3 of intestinal lymphoid cells and NKT cells, highlighting their role in immune regulation. In this review we report on how bile acids and their metabolitesmodulate the immune system in inflammations and cancers and could be exploiting for developing novel therapeutic approaches in these disorders.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101291"},"PeriodicalIF":14.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunology of bile acids regulated receptors\",\"authors\":\"Stefano Fiorucci ,&nbsp;Silvia Marchianò ,&nbsp;Ginevra Urbani ,&nbsp;Cristina Di Giorgio ,&nbsp;Eleonora Distrutti ,&nbsp;Angela Zampella ,&nbsp;Michele Biagioli\",\"doi\":\"10.1016/j.plipres.2024.101291\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from cholesterol metabolism, secondary bile acids represent the products of microbial enzymes. Close to 100 different enzymatic modifications of bile acids structures occur in the human intestine and clinically guided metagenomic and metabolomic analyses have led to the identification of an extraordinary number of novel metabolites. These chemical mediators make an essential contribution to the composition and function of the postbiota, participating to the bidirectional communications of the intestinal microbiota with the host and contributing to the architecture of intestinal-liver and -brain and -endocrine axes. Bile acids exert their function by binding to a group of cell membrane and nuclear receptors collectively known as bile acid-regulated receptors (BARRs), expressed in monocytes, tissue-resident macrophages, CD4+ T effector cells, including Th17, T regulatory cells, dendritic cells and type 3 of intestinal lymphoid cells and NKT cells, highlighting their role in immune regulation. In this review we report on how bile acids and their metabolitesmodulate the immune system in inflammations and cancers and could be exploiting for developing novel therapeutic approaches in these disorders.</p></div>\",\"PeriodicalId\":20650,\"journal\":{\"name\":\"Progress in lipid research\",\"volume\":\"95 \",\"pages\":\"Article 101291\"},\"PeriodicalIF\":14.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in lipid research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0163782724000249\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in lipid research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163782724000249","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

胆汁酸是在宿主新陈代谢和肠道微生物群界面形成的类固醇。一级胆汁酸在肝脏中由胆固醇代谢产生,而二级胆汁酸则是微生物酶的产物。人体肠道中会出现近 100 种不同的胆汁酸结构酶修饰,临床指导下的元基因组和代谢组分析发现了大量新型代谢物。这些化学介质对后生物群的组成和功能做出了重要贡献,参与了肠道微生物群与宿主的双向交流,并对肠-肝、脑和内分泌轴的结构做出了贡献。胆汁酸通过与一组统称为胆汁酸调控受体(BARRs)的细胞膜和核受体结合来发挥其功能,这些受体表达于单核细胞、组织驻留巨噬细胞、CD4+ T效应细胞(包括Th17)、T调节细胞、树突状细胞以及肠道淋巴细胞的3型和NKT细胞,突出了它们在免疫调节中的作用。在这篇综述中,我们报告了胆汁酸及其代谢产物如何在炎症和癌症中调节免疫系统,并可用于开发治疗这些疾病的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Immunology of bile acids regulated receptors

Bile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from cholesterol metabolism, secondary bile acids represent the products of microbial enzymes. Close to 100 different enzymatic modifications of bile acids structures occur in the human intestine and clinically guided metagenomic and metabolomic analyses have led to the identification of an extraordinary number of novel metabolites. These chemical mediators make an essential contribution to the composition and function of the postbiota, participating to the bidirectional communications of the intestinal microbiota with the host and contributing to the architecture of intestinal-liver and -brain and -endocrine axes. Bile acids exert their function by binding to a group of cell membrane and nuclear receptors collectively known as bile acid-regulated receptors (BARRs), expressed in monocytes, tissue-resident macrophages, CD4+ T effector cells, including Th17, T regulatory cells, dendritic cells and type 3 of intestinal lymphoid cells and NKT cells, highlighting their role in immune regulation. In this review we report on how bile acids and their metabolitesmodulate the immune system in inflammations and cancers and could be exploiting for developing novel therapeutic approaches in these disorders.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
期刊最新文献
How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting Increasing oil content in Brassica oilseed species Long chain polyunsaturated fatty acid (LC-PUFA) composition of fish sperm: nexus of dietary, evolutionary, and biomechanical drivers Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1