Yungang Tian , Jingjing Fan , Rongshen Wang , Rui Ding , Chunxue Zhao , Jia Xu , Qingyun Zhang , Tiegui Nan , Xianchan Li , Min Ye
{"title":"三七根中的三萜类皂甙对 APAP 引起的肝损伤具有保护作用","authors":"Yungang Tian , Jingjing Fan , Rongshen Wang , Rui Ding , Chunxue Zhao , Jia Xu , Qingyun Zhang , Tiegui Nan , Xianchan Li , Min Ye","doi":"10.1016/j.fitote.2024.106159","DOIUrl":null,"url":null,"abstract":"<div><p>Five previously undescribed protopanaxatriol-type saponins, notoginsenosides Ta-Te (<strong>1</strong>–<strong>5</strong>), together with eighteen known triterpenoid saponins (<strong>6</strong>–<strong>23</strong>) were isolated from the roots of <em>Panax notoginseng</em>. The structures of new compounds were determined by HRESIMS and NMR spectroscopic analyses and chemical methods. Compounds <strong>1</strong> and <strong>2</strong> were the first examples of ginsenosides featuring a 6-deoxy-<em>β</em>-<span>d</span>-glucose moiety from <em>Panax</em> species. Compounds <strong>1</strong>–<strong>4</strong>, <strong>7</strong>, <strong>10</strong>, <strong>12</strong>, <strong>21</strong>–<strong>22</strong> showed protective effects on L02 cells against the injury of acetaminophen (APAP). Among them, notoginsenoside R1 (<strong>12</strong>), ginsenoside Rg1 (<strong>21</strong>), and ginsenoside Re (<strong>22</strong>) were the most potent ones, with cell viabilities >80%. Moreover, compounds <strong>12</strong> and <strong>22</strong> remarkably alleviated APAP-induced liver injury in mice. These saponins are potential hepatoprotective agents.</p></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Triterpenoid saponins from the roots of Panax notoginseng with protective effects against APAP-induced liver injury\",\"authors\":\"Yungang Tian , Jingjing Fan , Rongshen Wang , Rui Ding , Chunxue Zhao , Jia Xu , Qingyun Zhang , Tiegui Nan , Xianchan Li , Min Ye\",\"doi\":\"10.1016/j.fitote.2024.106159\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Five previously undescribed protopanaxatriol-type saponins, notoginsenosides Ta-Te (<strong>1</strong>–<strong>5</strong>), together with eighteen known triterpenoid saponins (<strong>6</strong>–<strong>23</strong>) were isolated from the roots of <em>Panax notoginseng</em>. The structures of new compounds were determined by HRESIMS and NMR spectroscopic analyses and chemical methods. Compounds <strong>1</strong> and <strong>2</strong> were the first examples of ginsenosides featuring a 6-deoxy-<em>β</em>-<span>d</span>-glucose moiety from <em>Panax</em> species. Compounds <strong>1</strong>–<strong>4</strong>, <strong>7</strong>, <strong>10</strong>, <strong>12</strong>, <strong>21</strong>–<strong>22</strong> showed protective effects on L02 cells against the injury of acetaminophen (APAP). Among them, notoginsenoside R1 (<strong>12</strong>), ginsenoside Rg1 (<strong>21</strong>), and ginsenoside Re (<strong>22</strong>) were the most potent ones, with cell viabilities >80%. Moreover, compounds <strong>12</strong> and <strong>22</strong> remarkably alleviated APAP-induced liver injury in mice. These saponins are potential hepatoprotective agents.</p></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24003423\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24003423","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Triterpenoid saponins from the roots of Panax notoginseng with protective effects against APAP-induced liver injury
Five previously undescribed protopanaxatriol-type saponins, notoginsenosides Ta-Te (1–5), together with eighteen known triterpenoid saponins (6–23) were isolated from the roots of Panax notoginseng. The structures of new compounds were determined by HRESIMS and NMR spectroscopic analyses and chemical methods. Compounds 1 and 2 were the first examples of ginsenosides featuring a 6-deoxy-β-d-glucose moiety from Panax species. Compounds 1–4, 7, 10, 12, 21–22 showed protective effects on L02 cells against the injury of acetaminophen (APAP). Among them, notoginsenoside R1 (12), ginsenoside Rg1 (21), and ginsenoside Re (22) were the most potent ones, with cell viabilities >80%. Moreover, compounds 12 and 22 remarkably alleviated APAP-induced liver injury in mice. These saponins are potential hepatoprotective agents.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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