以巨噬细胞表型和代谢为靶点,作为动脉粥样硬化和相关心血管疾病的新型治疗方法。

IF 5.7 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Atherosclerosis Reports Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI:10.1007/s11883-024-01229-z
Juan Wang, Qiang Wu, Xinyu Wang, Hongbin Liu, Mulei Chen, Li Xu, Ze Zhang, Kuibao Li, Weiming Li, Jiuchang Zhong
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引用次数: 0

摘要

综述的目的:巨噬细胞的聚集和活化是动脉粥样硬化的标志,在动脉粥样硬化斑块的所有成分和阶段中具有复杂而错综复杂的动态变化。在这篇综述中,我们将重点讨论巨噬细胞表型和新陈代谢在动脉粥样硬化中的调控作用和内在机制。我们强调了动脉粥样硬化中巨噬细胞表型的多样性及其在动脉粥样硬化斑块的进展和消退中的潜在作用。此外,我们还讨论了开发预防和治疗动脉粥样硬化性心血管疾病的治疗策略所面临的挑战和机遇:巨噬细胞在促炎 M1 和抗炎 M2 表型之间的极化失调改变了动脉粥样硬化进展过程中的免疫炎症反应,导致斑块的形成、生长和最终破裂。巨噬细胞新陈代谢的改变是其功能和随后动脉粥样硬化性心血管疾病进展的一个关键特征。巨噬细胞的免疫代谢与动脉粥样硬化病灶内巨噬细胞的活化和代谢重构有关,从而改变了巨噬细胞的免疫效应和组织修复功能。针对巨噬细胞的表型和代谢是预防和治疗动脉粥样硬化和动脉粥样硬化性心血管疾病的潜在治疗策略。了解特定巨噬细胞亚群的精确功能和新陈代谢以及它们对动脉粥样硬化斑块的组成和生长的贡献,可以揭示延缓或阻止动脉粥样硬化性心血管疾病的发展及其相关病理生理后果的新策略。找出能够调节巨噬细胞表型和新陈代谢的生物刺激因素,可能会开发出治疗动脉粥样硬化和冠状动脉疾病患者的创新疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases.

Purpose of the review: Macrophage accumulation and activation function as hallmarks of atherosclerosis and have complex and intricate dynamics throughout all components and stages of atherosclerotic plaques. In this review, we focus on the regulatory roles and underlying mechanisms of macrophage phenotypes and metabolism in atherosclerosis. We highlight the diverse range of macrophage phenotypes present in atherosclerosis and their potential roles in progression and regression of atherosclerotic plaque. Furthermore, we discuss the challenges and opportunities in developing therapeutic strategies for preventing and treating atherosclerotic cardiovascular disease.

Recent findings: Dysregulation of macrophage polarization between the proinflammatory M1 and anti-inflammatory M2 phenotypealters the immuno-inflammatory response during atherosclerosis progression, leading to plaque initiation, growth, and ultimately rupture. Altered metabolism of macrophage is a key feature for their function and the subsequent progression of atherosclerotic cardiovascular disease. The immunometabolism of macrophage has been implicated to macrophage activation and metabolic rewiring of macrophages within atherosclerotic lesions, thereby shifting altered macrophage immune-effector and tissue-reparative function. Targeting macrophage phenotypes and metabolism are potential therapeutic strategies in the prevention and treatment of atherosclerosis and atherosclerotic cardiovascular diseases. Understanding the precise function and metabolism of specific macrophage subsets and their contributions to the composition and growth of atherosclerotic plaques could reveal novel strategies to delay or halt development of atherosclerotic cardiovascular diseases and their associated pathophysiological consequences. Identifying biological stimuli capable of modulating macrophage phenotypes and metabolism may lead to the development of innovative therapeutic approaches for treating patients with atherosclerosis and coronary artery diseases.

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来源期刊
CiteScore
9.00
自引率
3.40%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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