{"title":"塞拉斯托尔:从分离到生物技术生产以及开发抗肥胖药物的百年历程。","authors":"Yong Zhao, Karel Miettinen, Sotirios C. Kampranis","doi":"10.1016/j.pbi.2024.102615","DOIUrl":null,"url":null,"abstract":"<div><p>Celastrol, a triterpenoid found in the root of the traditional medicinal plant <em>Tripterygium wilfordii</em>, is a potent anti-inflammatory and antiobesity agent. However, pharmacological exploitation of celastrol has been hindered by the limited accessibility of plant material, the co-existence of other toxic compounds in the same plant tissue, and the lack of an efficient chemical synthesis method. In this review, we highlight recent progress in elucidating celastrol biosynthesis and discuss how this knowledge can facilitate its scalable bioproduction using cell factories and its further development as an antiobesity and anti-inflammatory drug.</p></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":"81 ","pages":"Article 102615"},"PeriodicalIF":8.3000,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369526624001067/pdfft?md5=d24e357146a4e0ccdac1ac69c116eee9&pid=1-s2.0-S1369526624001067-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug\",\"authors\":\"Yong Zhao, Karel Miettinen, Sotirios C. Kampranis\",\"doi\":\"10.1016/j.pbi.2024.102615\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Celastrol, a triterpenoid found in the root of the traditional medicinal plant <em>Tripterygium wilfordii</em>, is a potent anti-inflammatory and antiobesity agent. However, pharmacological exploitation of celastrol has been hindered by the limited accessibility of plant material, the co-existence of other toxic compounds in the same plant tissue, and the lack of an efficient chemical synthesis method. In this review, we highlight recent progress in elucidating celastrol biosynthesis and discuss how this knowledge can facilitate its scalable bioproduction using cell factories and its further development as an antiobesity and anti-inflammatory drug.</p></div>\",\"PeriodicalId\":11003,\"journal\":{\"name\":\"Current opinion in plant biology\",\"volume\":\"81 \",\"pages\":\"Article 102615\"},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2024-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1369526624001067/pdfft?md5=d24e357146a4e0ccdac1ac69c116eee9&pid=1-s2.0-S1369526624001067-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in plant biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1369526624001067\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624001067","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug
Celastrol, a triterpenoid found in the root of the traditional medicinal plant Tripterygium wilfordii, is a potent anti-inflammatory and antiobesity agent. However, pharmacological exploitation of celastrol has been hindered by the limited accessibility of plant material, the co-existence of other toxic compounds in the same plant tissue, and the lack of an efficient chemical synthesis method. In this review, we highlight recent progress in elucidating celastrol biosynthesis and discuss how this knowledge can facilitate its scalable bioproduction using cell factories and its further development as an antiobesity and anti-inflammatory drug.
期刊介绍:
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.