纳米技术在诊断和治疗恶性肿瘤方面的最新进展。

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-08-12 DOI:10.1038/s41392-024-01889-y
Bilan Wang, Shiqi Hu, Yan Teng, Junli Chen, Haoyuan Wang, Yezhen Xu, Kaiyu Wang, Jianguo Xu, Yongzhong Cheng, Xiang Gao
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引用次数: 0

摘要

癌症仍然是人类健康的重大威胁。纳米医学是一个新兴的多学科领域,正在引起人们的广泛兴趣和研究。纳米医学在癌症诊断和治疗方面显示出巨大的潜力。专门设计的纳米粒子可用作癌症诊断中的造影剂,通过成像检查实现高灵敏度和高分辨率的肿瘤检测。纳米探针和纳米生物传感器的使用也使肿瘤标记和检测的新方法成为可能。通过合理设计和制造纳米药物载体,可以在癌症治疗中实现靶向给药。纳米颗粒能够通过被动或主动的靶向过程将药物或基因片段有效地输送到肿瘤组织,从而提高治疗效果,同时最大限度地减少对健康组织的伤害。同时,纳米颗粒还可用于放射增敏和光热疗法,以提高对恶性肿瘤的疗效。本综述对纳米技术如何用于诊断和治疗恶性肿瘤进行了文献综述和总结。根据源自人体不同系统的肿瘤疾病,并结合不同部位癌症的病理生理特点,我们回顾了纳米技术应用的最新进展。最后,我们简要讨论了纳米技术在癌症中的应用前景和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors.

Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be accomplished through the rational design and manufacture of nanodrug carriers. Nanoparticles have the capability to effectively transport medications or gene fragments to tumor tissues via passive or active targeting processes, thus enhancing treatment outcomes while minimizing harm to healthy tissues. Simultaneously, nanoparticles can be employed in the context of radiation sensitization and photothermal therapy to enhance the therapeutic efficacy of malignant tumors. This review presents a literature overview and summary of how nanotechnology is used in the diagnosis and treatment of malignant tumors. According to oncological diseases originating from different systems of the body and combining the pathophysiological features of cancers at different sites, we review the most recent developments in nanotechnology applications. Finally, we briefly discuss the prospects and challenges of nanotechnology in cancer.

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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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