Takamune T Saito, Koki Yamamoto, Hirohito Minami, Taiki Tsujiue
{"title":"草履虫brc-1突变增加了him-8和zim-2突变体中COSA-1病灶的数量。","authors":"Takamune T Saito, Koki Yamamoto, Hirohito Minami, Taiki Tsujiue","doi":"10.17912/micropub.biology.001077","DOIUrl":null,"url":null,"abstract":"<p><p>Crossover designation factors such as COSA-1 are concentrated at the specific DNA double-strand break (DSB) sites to promote crossover formation. <i>zim-1</i> mutants, which show defects in the homologous chromosome pairing of chromosomes II and III, increase the COSA-1 foci/normal bivalent state compared to the expected value. The excess designation was suppressed by an additional mutation in <i>brc-1</i> in <i>zim-1</i> mutants. We demonstrated that the number of COSA-1 foci in <i>him-8</i> and <i>zim-2</i> mutants, showing defects in the pairing of the X and V chromosomes, respectively, increased compared to the expected value, and <i>brc-1</i> mutation accelerated the number of COSA-1 foci in oogenesis.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310775/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Caenorhabditis elegans brc-1</i> mutation increases the number of COSA-1 foci in <i>him-8</i> and <i>zim-2</i> mutants.\",\"authors\":\"Takamune T Saito, Koki Yamamoto, Hirohito Minami, Taiki Tsujiue\",\"doi\":\"10.17912/micropub.biology.001077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Crossover designation factors such as COSA-1 are concentrated at the specific DNA double-strand break (DSB) sites to promote crossover formation. <i>zim-1</i> mutants, which show defects in the homologous chromosome pairing of chromosomes II and III, increase the COSA-1 foci/normal bivalent state compared to the expected value. The excess designation was suppressed by an additional mutation in <i>brc-1</i> in <i>zim-1</i> mutants. We demonstrated that the number of COSA-1 foci in <i>him-8</i> and <i>zim-2</i> mutants, showing defects in the pairing of the X and V chromosomes, respectively, increased compared to the expected value, and <i>brc-1</i> mutation accelerated the number of COSA-1 foci in oogenesis.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2024 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310775/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001077\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Caenorhabditis elegans brc-1 mutation increases the number of COSA-1 foci in him-8 and zim-2 mutants.
Crossover designation factors such as COSA-1 are concentrated at the specific DNA double-strand break (DSB) sites to promote crossover formation. zim-1 mutants, which show defects in the homologous chromosome pairing of chromosomes II and III, increase the COSA-1 foci/normal bivalent state compared to the expected value. The excess designation was suppressed by an additional mutation in brc-1 in zim-1 mutants. We demonstrated that the number of COSA-1 foci in him-8 and zim-2 mutants, showing defects in the pairing of the X and V chromosomes, respectively, increased compared to the expected value, and brc-1 mutation accelerated the number of COSA-1 foci in oogenesis.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
