人类约 12 小时昼夜节律基因程序的证据

npj Biological Timing and Sleep Pub Date : 2024-08-09 DOI:10.1038/s44323-024-00005-1

Bokai Zhu, Silvia Liu, Natalie L. David, William Dion, Nandini K. Doshi, Lauren B. Siegel, Tânia Amorim, Rosemary E. Andrews, G. V. Naveen Kumar, Hanwen Li, Saad Irfan, Tristan Pesaresi, Ankit X. Sharma, Michelle Sun, Pouneh K. Fazeli, Matthew L. Steinhauser

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摘要

小鼠和许多海洋生物都表现出 ~12 小时的超昼夜节律，但人类却缺乏 ~12 小时超昼夜节律的直接证据。在这里，我们对三名健康人的外周白细胞进行了前瞻性的时间转录组分析。在涉及 RNA 和蛋白质代谢的分子程序中，所有三名参与者都独立地表现出了强烈的 ~12-h 转录节律，这与之前在蛇尾目海洋物种中发现的环流基因程序有很强的同源性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evidence for ~12-h ultradian gene programs in humans

Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.

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npj Biological Timing and Sleep

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