A Multi-Omics Analysis to Investigate the Co-Occurrence of Psoriasis and Crohn’s Diseases

Abstract

Psoriasis is a chronic autoimmune condition that causes rapid buildup of skin cells. Crohn’s disease is a chronic inflammatory bowel disease that affects the gastrointestinal tract. Psoriasis and Crohn’s disease are both chronic inflammatory disorders that are believed to share some common genetic and environmental risk factors. Aim of this study is to investigate possible link between psoriasis and Crohn’s disease through multi-omics approach. To obtain transcriptomics data of psoriasis and Crohn’s disease, four and three datasets of gene expression omnibus (GEO), as well as two proteomics datasets for each disease were used. Gene expression analysis, protein-protein network analysis and pathway enrichment were performed for differentially expressed genes and proteins. The main enriched pathway in psoriasis is interleukin-27-mediated signaling pathway, while for Crohn’s disease it was tryptophan catabolic process to kynurenine. The results showed that coding genes of IL-8, IL-10 and IL-17A are the main link between psoriasis and Crohn’s disease and in this link, Th1 plays an important role. On the other hand, it was also shown that METTL7A facilitates the infiltration of Th1 cells into the skin and colon tissue. Through this study, important molecules that involved in co-occurrence of the psoriasis and Crohn’s disease are introduced.