Xupei Men, Jie Song, Xiaomei Song, Xiangdong Qin, Du-Qiang Luo, Jun Zhang
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引用次数: 0
摘要
对 Corydalis mucronifera 进行化学研究的结果是，分离和鉴定了一对新的对映体酚类成分 (±)-mucroniferal D (1) 和五种已知的对映体酚类成分 (2-6)。根据质谱、一维和二维核磁共振的大量光谱数据分析，阐明了它们的结构，并通过比较旋光数据确认了它们的绝对构型。化合物 1-6 对 MCF-7、MGC-803 和 HeLa 细胞株表现出中等程度的细胞毒性活性，IC50 值范围为 22.61-98.30 μg-mL-1。
(±)-Mucroniferal D: a Pair of New Phenolic Enantiomers from Corydalis mucronifera
Chemical investigation of Corydalis mucronifera has resulted in the isolation and identification of a pair of new enantiomeric phenolic constituents (±)-mucroniferal D (1) and five known ones (2–6). Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the optical rotation data. Compounds 1–6 showed moderate cytotoxic activities against MCF-7, MGC-803, and HeLa cell lines with the IC50 values ranging from 22.61–98.30 μg·mL–1.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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