{"title":"以尿素为基础的 DES 作为获取含氮杂环的胺源","authors":"","doi":"10.1016/j.tetlet.2024.155224","DOIUrl":null,"url":null,"abstract":"<div><p>Herein, we report a urea-based DES that acts as an amine source in the synthesis of <em>N</em>-substituted styryl quinazolinone from anthranilic acid <em>via N</em>-acylation, cyclization, and subsequent sp<sup>3</sup> C<img>H functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urea-based DES as an amine source to access nitrogen-containing heterocycles\",\"authors\":\"\",\"doi\":\"10.1016/j.tetlet.2024.155224\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Herein, we report a urea-based DES that acts as an amine source in the synthesis of <em>N</em>-substituted styryl quinazolinone from anthranilic acid <em>via N</em>-acylation, cyclization, and subsequent sp<sup>3</sup> C<img>H functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003198\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003198","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
摘要
在此,我们报告了一种基于脲的 DES,该 DES 可作为胺源,在绿色反应介质下,通过蚁酸酰化、环化和随后的 sp CH 功能化合成-取代苯乙烯基喹唑啉酮。这种方法的突出特点是克级规模的合成、温和的反应条件和无金属方法。此外,还对后官能化和光物理性质进行了评估。
Urea-based DES as an amine source to access nitrogen-containing heterocycles
Herein, we report a urea-based DES that acts as an amine source in the synthesis of N-substituted styryl quinazolinone from anthranilic acid via N-acylation, cyclization, and subsequent sp3 CH functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.