TNF-α、皮质醇水平与 PM10 和 PM2.5 暴露之间的关系:一项试点研究

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Sciences Europe Pub Date : 2024-08-07 DOI:10.1186/s12302-024-00961-2
Jacopo Dolcini, Rosaria Landi, Elisa Ponzio, Laura Picchini, Aurora Luciani, Luca Formenti, Silvia Svegliati Baroni, Armando Gabrielli, Marcello Mario D’Errico, Pamela Barbadoro
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引用次数: 0

摘要

目的 对人类健康危害最大的大气污染物是颗粒物(PM)。我们分析了短期滞后暴露于 PM10 和 PM2.5、唾液皮质醇和 TNF-α 水平以及 TNF-α 启动子甲基化水平之间的相关性。每个受试者在一天中的不同时间采集 8 份唾液样本,以比较皮质醇水平和 TNFα 检测结果。分析唾液 DNA 上 TNFα 启动子甲基化水平。使用广义线性混合模型对不同结果与 PM10/PM2.54、3、2 和 1 天滞后值之间的关系进行回归分析,并使用广义加性混合模型(GAMM)评估任何可能的线性偏差。与升高有关的曲线下面积(AUCi)与 PM10 暴露的 4 天、3 天和 1 天滞后期呈统计学负相关。TNFα在4天、3天、2天和1天的滞后期与PM10和PM2.5这两种暴露都有统计学意义。TNF-α 的增加可能反映了污染暴露导致的氧化应激和炎症水平的增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Association between TNF-α, cortisol levels, and exposure to PM10 and PM2.5: a pilot study

Purpose

The most harmful atmospheric pollutant for human health is particulate matter (PM). We analyzed the correlation between short-term lag exposure to PM10 and PM2.5, salivary cortisol and TNF-α level, and methylation levels of the TNF-α promoter.

Methods

A pilot study including 20 subjects. Eight salivary samples for each subject at various times of the day were collected for comparing cortisol levels and TNFα detection. TNFα promoter methylation levels on salivary DNA were analyzed. Regression analyses were performed using generalized linear mixed models between the different outcomes and 4, 3, 2 and 1 day’s lag values of PM10/PM2.5.Generalized additive mixed model (GAMM) was used to evaluate any potential deviation from linearity.

Results

Area under the curve with respect to the ground (AUCg) showed a statistically positive association with 4-, 3-, 2-, and 1-day lag of exposure to PM10. Area under the curve with respect to the increase (AUCi) showed a statistically negative association with 4-, 3- and 1-day lag of exposure to PM10. TNFα showed statistically significant association with both exposures, PM10 and PM2.5, at 4-, 3-, 2-, and 1-day lag.

Conclusions

Regarding cortisol levels there is an increase of overall hormone levels but a less dynamism of the system to answer to external stressors. Increase of TNF-α may reflect increased levels of oxidative stress and inflammation due to pollution exposure.

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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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