伊昔单抗改善了伴有弥漫性脱发的难治性红皮病型银屑病：随访 52 周的病例报告

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-08 DOI:10.2147/ccid.s471582

Biao Song, Xiaohan Liu, Hongzhong Jin

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引用次数: 0

摘要

摘要：红皮病型银屑病（EP）是银屑病的一种严重而罕见的变异型，发病率不到 3%。其特征是广泛的鳞屑和红斑，影响超过 90% 的体表面积。脱发可能是与该病相关的一种症状，进一步加剧了对患者生活质量的影响。我们介绍了一例患有严重 EP 和弥漫性脱发且对传统疗法无效的患者。随后，该患者按照标签上的用法接受了ixekizumab治疗，结果银屑病皮损（银屑病面积和严重程度指数/PASI 100）和脱发（脱发严重程度工具/SALT 0）均完全消退。关键词：红皮病型银屑病；脱发；ixekizumab

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Ixekizumab Improved Refractory Erythrodermic Psoriasis with Comorbid Diffuse Alopecia: A Case Report with 52-Week Follow-Up

Abstract: Erythrodermic psoriasis (EP) is a severe and rare variant of psoriasis, accounting for less than 3% of cases. It is characterized by widespread scaling and erythema that affects more than 90% of the body surface area. Alopecia can manifest as a symptom associated with the disease, further exacerbating the impact on the patient’s quality of life. We present the case of a patient with severe EP and diffuse alopecia who did not respond to conventional therapies. The patient was subsequently treated with ixekizumab as per labeled usage, resulting in complete resolution of both psoriatic skin lesions (Psoriasis area and severity index/PASI 100) and alopecia (The Severity of Alopecia Tool/SALT 0).

Keywords: erythrodermic psoriasis, alopecia, ixekizumab

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.