用降压球进球缺氧敏感的[70]富勒烯纳米疗法

IF 17.3 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Matter Pub Date : 2024-08-07 DOI:10.1016/j.matt.2024.05.039

Martyna Krzykawska-Serda , Qian Feng , Maciej Serda

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引用次数: 0

摘要

Li 等人报道了一种新型低氧敏感富勒烯基纳米治疗系统在癌症光动力疗法中的开发和应用。该系统集成了[70]富勒烯支架、氨基修饰环糊精和缺氧激活抗癌原药替拉帕扎胺，并用肿瘤靶向肽和二硫键供体进行了增强。这种富勒烯纳米材料具有更强的水溶性和靶向特异性，可在肿瘤组织中进行选择性蓄积。

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Score a goal with buckyballs: Hypoxia-sensitive [70]fullerene nanotherapeutics

Li et al. reported the development and application of a novel hypoxia-sensitive fullerene-based nanotherapeutic system for photodynamic therapy in cancer treatment. This system integrates a [70]fullerene scaffold with amino-modified cyclodextrin and the hypoxia-activatable anticancer prodrug tirapazamine, enhanced with tumor-targeting peptides and disulfide bond donors. The created fullerene nanomaterial exhibits selective accumulation in tumor tissues, facilitated by its enhanced water solubility and targeted specificity.

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来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.