含有羰花青染料和月桂酸离子的荧光三元聚集体，可在成像引导下将亲水性药物输送到组织中

IF 0.8 Q3 Engineering Nanotechnologies in Russia Pub Date : 2024-08-06 DOI:10.1134/S2635167624600378

A. A. Luenkova, I. A. Doroshenko, T. A. Podrugina, M. K. Beklemishev

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引用次数: 0

摘要

摘要为了对亲水性药物进行成像，获得了庆大霉素和长春瑞滨与在光谱近红外区域具有荧光的碳青素染料以及作为反离子的月桂酸盐离子的聚集体。为了分离聚合体，采用了从成分水溶液中沉淀的方法。庆大霉素的聚集体大小在 200 至 600 nm 之间；长春瑞滨的聚集体大小在 400 至 1000 nm 之间；表面ζ电位在 -15...-5 mV 范围内变化。这些聚集体会被鸡的皮下脂肪组织、肌肉、骨骼和内皮组织吸附。将来，所产生的聚集体可用于可视化活生物体组织的药物输送。

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Fluorescing Ternary Aggregates Containing a Carbocyanine Dye and Laurate Ion for Imaging-Guided Delivery of Hydrophilic Drugs to Tissues

For the purpose of imaging hydrophilic drugs, aggregates of gentamicin and vinorelbine with carbocyanine dyes fluorescing in the near-infrared region of the spectrum and a laurate ion as a counterion are obtained. To isolate the aggregates, precipitation from an aqueous solution of components is used. The size of the aggregates with gentamicin range from 200 to 600 nm; with vinorelbine, from 400 to 1000 nm; the surface ζ potential varies in the range of –15…–5 mV. The aggregates are sorbed by the subcutaneous fatty tissue, muscle, bone, and endothelial tissues of chickens. In the future, the resulting aggregates can be used to visualize drug delivery to the tissues of living organisms.

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.